Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551039
Pertenecen a esta colección Tesis y Trabajos de grado de las Maestrías correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
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- Exploring the research landscape of 3D printing in oral drug delivery systems for central nervous system diseases(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2025-06-10) Paipa Jabre Cantú, Samir Ibrahim; Rodríguez Salvador, Marisela; emimmayorquin; Tercero Gómez, Víctor Gustavo; School of Engineering and Sciences; Campus Monterrey; Zhang, Y. ShrikeThe pharmaceutical industry faces increasing demands for innovative and personalized treatments that conventional manufacturing methods often struggle to meet. Three-dimensional printing (3DP) offers tailored solutions through customized oral drug delivery systems, enabling precise control over dosage, geometry, release kinetics, and gastrointestinal absorption—factors especially critical in therapies for central nervous system (CNS) disorders. This study applies a Competitive Technology Intelligence (CTI) approach to analyze advancements in 3DP for oral drug delivery, with a focus on Fused Deposition Modeling (FDM), Semi-Solid Extrusion (SSE), Stereolithography (SLA), Digital Light Processing (DLP), Selective Laser Sintering (SLS), and Binder Jetting (BJ). FDM emerges as the most widely used technique due to its cost-effectiveness and versatility for thermostable drugs (e.g., carbamazepine), while SSE proves optimal for thermolabile compounds (e.g., levetiracetam) due to its room-temperature operation. SLA and DLP enable complex geometries for controlled release, and BJ supports scalable production, exemplified by the commercial formulation Spritam®. Key findings highlight patient-centric applications such as pediatric-friendly formulations (e.g., flavored orodispersible films), geriatric-adapted designs (e.g., easy-to-swallow tablets), and accessible formats for patients with disabilities (e.g.,Braille-marked pills). Current challenges include limitations in printable materials (e.g., polymer compatibility) and the lack of regulatory standardization. By mapping these technologies and their therapeutic implications, this thesis offersactionable insights for stakeholders in the pharmaceutical, healthcare, and 3DP sectors to support the development of personalized dosing strategies, combination therapies, and improved treatment adherence in CNS care.
- Applying competitive technology intelligence to reveal advances in final end user applications, user acceptability, quality assurance, and digital technologies of 3D printing for oral drug delivery systems(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2023-06-12) Ríos Mata, Verónica Lissette; Rodríguez Salvador, Marisela; puemcuervo, emimayorquin; Smith Cornejo, Neale Ricardo; Bourguet Díaz, Rafael Ernesto; School of Engineering and Sciences; Campus MonterreyThe demands for high-value innovative treatments, investment in Research and Development (R&D), and personalized medicines are shaping the pharmaceutical industry, for this, current manufacturing methods may not be able to satisfy these needs. Three-dimensional printing offers different solutions for specific needs that cannot be attended due to the high cost of production, limitations on the process, or individualized demands. 3D printing oral drug delivery systems enhance the delivery of a pharmaceutical substances in the body and the dynamics between pharmaceutical ingredients, while providing personalized formulation, geometry, size, controlled release rate and time on the gastrointestinal tract. On the other hand, for a company to stay relevant in the market, it should be able to develop and integrate a sustainable differentiation, also known as a long-term competitive advantage (Porter, M., 1996). This competitive advantage can be based on the introduction and acquisition of new technologies. The process of identifying market opportunities, trends and new technologies is not always direct, for this, Competitive Technology Intelligence methodology and Scientometric analysis are utilized to reveal technological knowledge and technologies, in order to identify trends that can be turned into actionable information. The aim of this thesis is to use Competitive Technology Intelligence (CTI) methodology to reveal advances in Final End User Applications, User Acceptability, Quality Assurance, and Digital Technologies of 3D Printing for Oral Drug Delivery Systems and facilitate decision-making to stakeholders, upper management, firms or people belonging to the pharmaceutical, medical, healthcare and 3D printing area. Using a query developed from the CTI methodology a total of 621 papers from 01-01-1900 to 05-01-2023, after the database cleaning process the number of results decreased to 512. The 512 publications were categorized into 9 classifications, where the 149 corresponding to the categories Final End User Applications, User Acceptability, Quality Assurance, and Digital Technologies were analyzed. The results demonstrated a tendency towards digitalization of the industry, that looks forward to migrating clinical trials to digital solutions. Machine Learning is being used to optimize and predict parameters of the process and the behavior of the formulations. Applications like DEFEND3D are being examined to avoid the cyber risks of remote digital transfer of electronic prescriptions to the 3D printer. Quality assurance is one of the main concerns while developing 3D printed oral drug delivery systems. Quality by Design (QbD) approach is being used to efficient the design of a product. At the same time, protocols to standardize compounding procedures (mixing, preparation, and printing) as well as decision maps to facilitate decision-making of the pharmacist are being developed. The integration of all these methods can lead to quality assurance in the different types of dosage forms. In the Final End User application trend, abuse-deterrent 3D printed oral dosage forms are being designed to limit the accessibility to non-prescribed opioids, as a solution to the opioid abuse world crisis. For disease treatment, 3D printed capsules that permit the intake of multiple drugs and avoid the negative interactions between active pharmaceutical ingredients are being developed. User preferences and palatability are also being taken into consideration while designing 3D printed dosage forms, as it can facilitate their entry to the market.
- Using competitive and technology intelligence to determine 4D printing technology advances in health considering design factors and applications.(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2023-05) Martínez de Anda, Angelica Anette; RODRIGUEZ SALVADOR, MARISELA; 20562; Rodríguez Salvador, Marisela; puemcuervo, emipsanchez; Bourguet Díaz, Rafael Ernesto; Smith Cornejo, Neale Ricardo; School of Engineering and Sciences; Campus MonterreyCurrently there is an increasing demand in the medical field for low-cost, high-quality products as well as personalized solutions, and different manufacturing methods are being investigated to provide innovative solutions. Four-dimensional (4D) printing is a promising technology to solve challenges associated with applications of 4D printing in regenerative medicine and biomedical devices. A revolution is expected to come in this regard, and it is essential to keep abreast of the latest developments. Under this context, the purpose of this thesis is to determine 4D printing technology advances in the medical field, considering design factors and applications, using a Competitive Technology Intelligence (CTI) methodology. For this aim, publications were analyzed from the Scopus database between January 1, 2017, and May 9, 2023. The main trends were identified for both Design Factors and Applications. In the first case, the following were considered: 4D printing methods, external stimuli, materials, mathematical models, interaction mechanisms, and deformation mismatch, while in the second case, the applications of 4D printing involved were considered: drug delivery systems, stents, and scaffolds. The obtained Design Factors results included improvements in mechanical properties of hydrogels by adding magnetic nanoparticles, bio-polyurethan, and other materials, the development of cell-friendly bioprinting methods to print cellular structures, and the use of theoretical-experimental approaches to predict shape deformation of structures. While for Applications, results included advances in the development of expandable drug delivery systems, fabrication of stents for treatment of vascular and tracheal stenosis, and the design of scaffolds for the treatment of cartilage defects and bone regeneration. This research contributes to researchers, academics, and companies involved in Research and Development (R&D) and Innovation looking for new solutions to improve health incorporating breakthrough technologies such as 4D printing.
- Using Competitive Technology Intelligence to Determine Potato Peel Upcycling Trends and Applications(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2022-11-20) Fox Miranda, Itzel; TEJADA ORTIGOZA, VIRIDIANA ALEJANDRA; 420889; Rodríguez Salvador, Marisela; emipsanchez; Tejada Ortigoza, Viridiana Alejandra; Hernández Brenes, Carmen; School of Engineering and Sciences; Campus MonterreyIn the potato processing industry, specifically in potato chip manufacturing, potato peel is one of the main byproducts. Potato peel needs to be treated and managed properly to prevent environmental damage and promote economic growth through its use by innovating traditional processes, technologies, and products. In this context, Competitive Technology Intelligence (CTI) is a tool that provides relevant knowledge to support decision-making and strategic planning, that can create value in potato peel processing. For this reason, this thesis applied a CTI methodology using scientometric, patentometric, and product market analysis to reveal scientific and technological developments in potato peel byproduct. A Global Query was developed by an iterative process with expert feedback to retrieve scientific documents and published patents from renowned databases, published from January 1st, 2018, to April 30th, 2023. After deduplication and a manual verification process, 393 scientific publications and 82 published patents were collected. The publications were manually classified based on the publication focus in three main categories: Application, Process, and Economic Analysis. The growth kinetics, top journals and countries, and number of citations were determined. Market information was gathered from renowned databases and customer needs, industry development, and potato peel products on the market were identified. Potato peel identified applications were as a substrate, adsorbent, biopolymer, antioxidant, agriculture component, animal and insect feed, and functional ingredient. The main processing techniques were bioactive compounds and biopolymers extraction and pretreatment. The most prolific countries from scientific documents were India, Egypt, and China, and the intellectual property (IP) offices with the most published patents were China National Intellectual Property Administration, World Intellectual Property Organization, and Intellectual Property India. Potato peel research publication rate was affected by global COVID-19 pandemic. Furthermore, consumers desire to lower their environmental impact and need products that are plastic-free, benefit their health, and help them to adapt to harsh weather conditions. In addition, there is a need to promote the term upcycle since many consumers are not familiarized with it, and the ones who do relate it with reducing waste.
- 4d printing research trends and applications in the medical field: a scientometric analysis(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2022-07-28) Padilla Aguirre, Karen Marcela; RODRIGUEZ SALVADOR, MARISELA; 20562; Rodríguez Salvador, Marisela; emijzarate, emipsanchez; Urbina Coronado, Pedro Daniel; Elizondo Noriega, Armando; Escuela de Ingeniería y Ciencias; Campus MonterreyInnovation plays a key role on a company’s either success or failure. But innovation is not just the creating or adopting new technologies; it is also directly connected with a solid strategic planning. Competitive technology intelligence is based on the systematic and ethical process of gathering, analyzing and transforming information into actionable knowledge. It aims to support decision making and strategic planning, because the knowledge produced by this methodology constitutes an early warning for research, development and innovation [19]. Three-dimensional (3D) printing is a technique of additive manufacturing that has revolutionized engineering, product design and manufacturing, as it allows the rapid conversion of digital 3D model information into physical static objects [45]. However, in the last few years a new possibility has been introduced to add ’time’ as a new dimension to create 4D printing. The medical field keeps changing and progressing at a high speed with new technologies emerging every day. 4D printing on the medical field is an area where it is necessary to provide decision makers with an overview of technological knowledge that helps them generate innovation opportunities. On this thesis, a Competitive technology intelligence approach was executed to identify trends in 4D printing technologies applied to the medical field, in order to provide relevant information through a technological landscape to support decision makers to uncover innovation opportunities. The results of the analysis revealed that most of the research developed is on the materials category, which relates completely to the fact that smart materials are the key difference between 3D and 4D printing. Most of the researches focus on shape memory polymers, hydrogels and liquid crystal elastomers. On the processes category researched is focused on the physical configuration of the printing model, printing parameters and adapting machines to modify the printing configurations. As for the applications, three main subcategories were identified, hollow tubes/stents, tissue engineering and drug delivery. According to the growth kinetics it is a field that although is fairly new, keeps growing and will keep gaining attention.
- Revealing a knowledge landscape on sustainable alternatives for plastic materials in takeaway food packaging(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2021-12-03) Oviedo González, María Marcela; RODRIGUEZ SALVADOR, MARISELA; 20562; Rodríguez Salvador, Marisela; puemcuervo; Takeda Toda, Naoko; Muñiz Rivera, Gerardo; School of Engineering and Sciences; Campus MonterreyPlastics have been among the most commonly used materials for food packaging solutions, especially in the takeaway sector because of their convenient features such as flexibility, low cost of production, their durability and most importantly they keep their edible contents safe and in a good state (British Plastics Federation, 2021). Nevertheless, in the last decade, as the use of plastics in takeaway food packaging has risen, the amount of waste and pollution has created a negative impact on the environment (Takeaway Packaging, 2021). The purpose of this thesis will focus on revealing sustainable alternatives for plastic materials in takeaway food packaging, to generate a knowledge landscape for decision making. The application of Competitive and Technology Intelligence (Rodriguez- Salvador, et.al., 2017) strategically evaluates science and technology to reveal the current global trends as well as the most prolific countries and organizations to obtain opportunities for innovation, while enabling the inclusion of diverse analytical methods to enrich the information analysis process. Thus, the Design Futures’ Design Fiction (Kelleher & Byrne, 2015) approach was incorporated in this process to better understand the situations behind the research foci, creating speculation on how the future of alternatives for plastic materials in takeaway food packaging applications could preferably be and how it might be attainable, facilitating the decision-making process. The information resources for this thesis were scientific publication records from SCOPUS and Web of Science database platforms that ran from Jan. 1st, 2017, to Nov. 5th, 2021. A sub-categorization of sustainable alternatives to plastic materials in takeaway food packaging was made to perform a thorough search: “Paper & Cardboard”, “Metals”, “Natural Fibers” and “Biodegradable Polymers”. These are the current material solutions available on the market. Competitive and Technology Intelligence revealed the current global trends on sustainable alternatives for plastics in takeaway food packaging as well as the most prolific countries and organizations in terms of developing scientific research. China and Malaysia are the top publication countries. Educational Institutions are leading the research on sustainable material alternatives for plastics, The Universiti Putra Malaysia (Malaysia) is the top affiliation with most published articles in this field. Experts interviewed agreed that the sole practice of replacing plastic materials in single-use takeaway food packaging is not enough to tackle the current plastic pollution problem, as a recycling culture needs to be practiced at home, “users who consume food packaging and do not discard it properly are the problem”. The utilization of the Design Fiction scope through the employment of the Affinity Diagram by Design Futures’ Contextual Design Fiction (Holtzblatt K. & Beyer H., 2014), helped to better understand the situations behind the research foci for the 4 sub-categories and to create speculation on how the future of sustainable alternatives for plastic materials in takeaway food packaging applications could preferably be and how it might be attainable. It also helped to imagine undesirable future pathways as a way of avoiding failure in the near future by addressing the information obtained from research through Competitive and Technology Intelligence. Long-term sustainability must assess the elimination of waste products and the integration into the circular economy to comply with regulations set by the European Union, which will represent a pivotal decision-making asset to consider when launching new sustainable alternatives to plastic food packaging solutions on the market. Further assessments on the disposal behaviors within society should be made, as well as takeaway food packaging needs to lengthen the time they are used rather than being disposed. The findings of this thesis help the decision-making process of food industry stakeholders and R&D to support initiatives and applications of alternatives for takeaway food packing. The strategic vision obtained from the Competitive Technology Intelligence-Design Fiction approach can be further explored by researchers as a guide to reveal advances in other areas of study.
- Application of competitive technology intelligence on HVAC systems for green buildings(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2020-12-01) Benavides Reyes, Victor Manuel; RODRIGUEZ SALVADOR, MARISELA; 20562; Rodríguez Salvador, Marisela; qrotbecerra/puemcuervo; Romero Díaz, David Carlos; Ugalde Hernández, Alan; School of Engineering and Sciences; Campus Monterrey; Morales Menéndez, RubénDuring the last two decades, Heating, Ventilation, and Air Conditioning (HVAC) power consumption have been approximately 50% of the total utilized in the building and construction sector, which equivalent to 10-20% of the total energy consumed worldwide (Perez-Lombard et al., 2011). The global need to optimize operation costs, save energy, and develop more sustainable offices, is driving the development of new technology trends with more sustainable and climate benefits. These trends are generating new codes and regulations applied to these areas, where federal agencies and municipalities offer economic incentives that make investments in green buildings more attractive. The objective of this thesis is to explore existing technology trends focused on energy efficiency, indoor air quality, ventilation, and sustainability, using a Competitive Technology Intelligence (CTI) methodology to identify the key drivers on energy consumption and discover opportunities to innovate towards more efficient systems. This methodology provides insight into opportunity areas such as integrated systems design and innovation in software that allows better flexibility in maintaining the required energy, air management, comfort levels, indoor air quality, and sustainability. Energy demand on HVAC systems varies according to season and climate zone; depending on design and configuration, different applications in several cases might reach up to 21% annual energy savings (Vakiloroaya et al., 2014). Based on a study on cost analysis and technical evaluations, the return of investment values for HVAC systems applications might oscillate between 2 -11 years (in the best scenario) in terms of energy consumption benefits (Marino & Minichiello, 2015). They also may have other benefits, such as the possibility of using renewable energy sources, improving indoor air quality, creating a clean and healthy environment, and low CO2 emissions.
- Modelo de evaluación de tecnología basado en la conjunción de análisis de patentes y roadmapping(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2008-05-01) Lugo Medina, Jorge Norberto; Lugo Medina, Jorge Norberto; 228745; Rodríguez Salvador, Marisela; ITESM-Campus Monterrey
- Integración de la Inteligencia Competitiva y Tecnológica dentro del Proceso de Diseño de Productos-Edición Única(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2006-12-01) Cisneros Reyes, Angélica; Rodríguez Salvador, Marisela; León Rovira,Noel; Hernández Luna, Alberto; ITESM-Campus Monterrey; Mariñez Navarro, FreddySe mencionan brevemente los sucesos más importantes en la historia de la Inteligencia Competitiva y Tecnológica, su definición, así como su importancia, para continuar con la historia y definición del Proceso de Diseño de Productos. Los aspectos más importantes de los temas fundamentales para la realización de este proyecto, la Inteligencia Competitiva y Tecnológica y el Proceso de Diseño de Productos. Como primera parte se hará un breve resumen de la historia de cada uno de estos campos para continuar con la definición, importancia y objetivos de cada uno de ellos. Se continuará con la descripción de las técnicas más utilizadas en cada uno de los campos. El método a desarrollar esta basado en el modelo conceptual desarrollado para la integración de la Inteligencia Competitiva y Tecnológica en el Proceso de Diseño de Productos descrito en el apartado 2.3. El método consiste en dos etapas con el caso de estudio consiste en llevar a cabo la integración de los sistemas de inteligencia en el proceso de diseño de un bloque de puesta a tierra (Ground block). La elección de este producto para el desarrollo del caso de estudio se determinó por las siguientes razones: • Debido a la relevancia del proyecto para la empresa. Este producto pertenece a la familia “Bonding & Grounding Hardware”, la cual de acuerdo a la información disponible en la empresa mostrada en el Anexo 1, representa el 30% de las ventas de la División con aproximadamente un 23% de margen de ganancia y se considera un mercado en crecimiento y por lo tanto una oportunidad. • Debido a que es un producto que se desarrollará en la empresa en la que actualmente trabajo como Ingeniero de Diseño y existe la facilidad de acceso a la información y los contactos necesarios para desarrollar el caso de estudio.
- Mapeo tecnológico usando systematic layout planning (SLP): el caso de la investigación en biomateriales(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2003-02-01) Olivares Benítez, Elias; Olivares Benítez, Elías; 253922; Rodríguez Salvador, Marisela; Caballero Gómez, Alberto Adán; Molina Solís, Juan Oscar; Programa de Graduados en Ingeniería; Campus MonterreyEn este trabajo se propone un método basado en el proceso de la Inteligencia Competitiva Tecnológica orientado al uso del Mapeo Tecnológico para definir las tecnologías estratégicas y la evolución cronológica de un campo de la investigación científica. La Inteligencia Competitiva se ha formalizado como una disciplina que busca analizar el entorno competitivo de una empresa para transformar los datos desagregados acerca de los competidores, industria y clientes en conocimiento que permita tomar decisiones estratégicas que mejoren el posicionamiento competitivo de la organización. Al momento de la elaboración de este trabajo, la Inteligencia Competitiva destaca como un tema novedoso en México, aunque se aplica ampliamente en países líderes en el mundo como Estados Unidos, Alemania, Francia, Reino Unido y Japón. Uno de los elementos analizados por esta disciplina es la Tecnología, formando la rama de la Inteligencia Competitiva Tecnológica. Entre las herramientas de ésta rama se encuentra el Mapeo Tecnológico, que tiene la finalidad de analizar un campo de la ciencia o la tecnología para definir sus temas estratégicos y su evolución cronológica. Un Mapa Tecnológico es una representación del conocimiento de un campo científico o tecnológico en dos o tres dimensiones, donde los elementos en el mapa se refieren a temas y tópicos, como ciudades en un mapa geográfico. En estos mapas, los elementos se posicionan en relación con los otros, de tal forma que los tópicos que están relacionados cognoscitivamente están posicionados cercanamente, y aquellos que no están relacionados fuertemente se encuentran distantes. Aunque se han propuesto muchas técnicas para la elaboración de Mapas tecnológicos, éstas en general resultan muy sofisticadas y costosas, reduciendo su oportunidad de ser aplicadas ampliamente. Por ello, en este trabajo se propone una técnica basada en la integración del Systematic Layout Planning y el Análisis de Aparición Conjunta de Palabras, que presenta ventajas para aplicarse en una gran cantidad de áreas y por diversos tipos de organizaciones. La técnica de Mapeo propuesta se integró en un proceso de Inteligencia Competitiva Tecnológica, lo que permite que pueda tener diversas aplicaciones en los ámbitos científicos y tecnológicos. Para probar la efectividad del método propuesto, éste se aplicó en el caso de estudio de la investigación en Biomateriales considerando que éste ha sido identificado como un campo que será de gran importancia en el futuro de la investigación científica. Los resultados del análisis de este caso de estudio se sometieron a la opinión de especialistas de Alemania, Japón y Australia, encontrando positiva la valoración en general. Entre las conclusiones del caso de estudio se identifican como los temas más importantes: Hidroxiapatita (biomaterial), Hueso (tejido), Implante (aplicación). Se identifican también otros temas en crecimiento. Se identifican a los autores con mayor producción de publicaciones entre los documentos analizados, así como sus grupos de colaboración. Se confirma el liderazgo de Estados Unidos, Reino Unido, Japón y Alemania en la investigación en este campo. También se revela la participación de Italia en este grupo de liderazgo, y se pone de manifiesto la debilidad de México en esta área. De esta manera, finalmente se confirmó la utilidad del método propuesto para identificar los temas estratégicos y la evolución cronológica de un campo de investigación científica cumpliendo con los objetivos del proyecto.