Changes in the activity of CYP450 3A4 induced by kaempferol 3-O-glucoside, major flavonol found in black bean (Phaseolus vulgaris) seed coat extract.

Abstract

Supplements have increase the popularity of herbal medicine as complementary and/or alternative therapies in the treatment of many disorders, because of this there is a potential possibility for pharmacokinetic and pharmacodynamics interaction between xenobiotics. The health promoting effects of natural foods and dietary supplements containing herbal constituents is believed to be caused by the antioxidant activity of flavonoids. Black bean flavonoids have been shown to have biological effects as antimicrobials, anti-inflammatory, anticholesterolemic, and have anticancerous properties. These interactions can attenuate or enhance drug effects and toxicity by interfering with permeability, phase I metabolism and the antioxidant activity of flavonoids. Keywords: pharmacokinetics, pharmacodynamics, drug interactions, CyP450, hepatocytes, HepG2, Caco2, permeability, cellular antioxidant activity, flavonoids, black bean, quercetin, kaempferol, CPC