Novel PEGylation and purification strategies for the development of biopharmaceutical products

Campos García, Víctor Raúl; CAMPOS GARCIA, VICTOR RAUL; 529594

Novel PEGylation and purification strategies for the development of biopharmaceutical products

dc.audience.educationlevel	Investigadores/Researchers	es_MX
dc.contributor.advisor	González Valdez, José Guillermo
dc.contributor.author	Campos García, Víctor Raúl
dc.contributor.cataloger	emipsanchez	es_MX
dc.contributor.committeemember	Pérez Ramírez, Néstor Octavio
dc.contributor.committeemember	Martínez Calderón, Luz María
dc.contributor.committeemember	Gradilla Hernández, Misael Sebastián
dc.contributor.department	Escuela de Ingeniería y Ciencias	es_MX
dc.contributor.institution	Campus Monterrey	es_MX
dc.contributor.mentor	Benavides Lozano, Jorge Alejandro
dc.creator	CAMPOS GARCIA, VICTOR RAUL; 529594
dc.date.accepted	2021-08
dc.date.accessioned	2021-10-04T03:41:10Z
dc.date.available	2021-10-04T03:41:10Z
dc.date.embargoenddate	2023-08-30
dc.date.issued	2021-08
dc.description	https://orcid.org/0000-0001-6734-8245	es_MX
dc.description.abstract	This work presents alternative and novel PEGylation reaction and purification strategies to develop biopharmaceutical products using three PEGylated proteins as models: PEGfilgrastim, PEGRNase A and PEGlysozyme. These strategies are presented as improvements of traditional PEGylation reactions schemes that involve sequential reaction and purification steps. The present dissertation is divided in five chapters. The first chapter serves as an introduction of the topic giving the general background regarding PEGylation as a technique to develop long- acting therapeutics and the methodologies used for its analysis. The results of the experiments herein proposed are presented in Chapter 2, Chapter 3 and Chapter 4, included in published or submitted scientific papers. The general conclusions of the dissertation are presented in Chapter 5, including perspectives for further studies in the same work line.	es_MX
dc.description.degree	Doctor en Biotecnología	es_MX
dc.format.medium	Texto	es_MX
dc.identificator	2\|\|23\|\|2399\|\|239999	es_MX
dc.identifier.citation	Campos-García, VR (2021). Novel PEGylation and purification strategies for the development of biopharmaceutical products. (Tesis Doctorado). Instituto Tecnológico y de Estudios Superiores de Monterrey, Nuevo León, México. Recuperado de: https://hdl.handle.net/11285/639811	es_MX
dc.identifier.cvu	529594	es_MX
dc.identifier.orcid	https://orcid.org/0000-0001-7968-9928	es_MX
dc.identifier.scopusid	55879161700	es_MX
dc.identifier.uri	https://hdl.handle.net/11285/639811
dc.language.iso	eng	es_MX
dc.publisher	Instituto Tecnológico y de Estudios Superiores de Monterrey	es_MX
dc.relation	Consejo Nacional de Ciencia y Tecnología (CONACyT). Número de beca. 492135	es_MX
dc.relation.isFormatOf	versión publicada	es_MX
dc.rights	embargoedAccess	es_MX
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0	es_MX
dc.subject.classification	BIOLOGÍA Y QUÍMICA::QUÍMICA::OTRAS ESPECIALIDADES QUÍMICAS::OTRAS	es_MX
dc.subject.keyword	PEGylation	es_MX
dc.subject.keyword	Novel strategies	es_MX
dc.subject.keyword	Biopharmaceuticals	es_MX
dc.subject.keyword	Reactive ATPS	es_MX
dc.subject.keyword	On-monolith PEGylation	es_MX
dc.subject.lcsh	Science	es_MX
dc.title	Novel PEGylation and purification strategies for the development of biopharmaceutical products	es_MX
dc.type	Tesis de doctorado