Design and fabrication of bioreactors for tissue engineering

Abstract

Tissue engineering (TE) has provided new techniques to create better tissue models, for study or to solve actual medical problems. Combining TE with design and 3D manufacture techniques can achieve devices that improve actual models. 3D tissue models present a diffusion problem that causes cell death because of the lack of oxygen and nutrients and the concentration of cell waste. Proving flow to the constructs can facilitate perfusion and enhance tissue. To do so, this document presents the designs and prototype development of two bioreactors, with the objective of diminishing necrotic core to create relevant implantable bone tissue and a more realistic breast cancer model. Using DLP and commercially available parts, designs were prototyped and validated.