Ciencias Exactas y Ciencias de la Salud

Now showing 1 - 3 of 3

Follow up of longlived dropletsize stability in O/W nanoemulsions for antibacterial applications and their thermoresponsive behaviour
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2025-05-09) Erick Jair, Sánchez Gaitán; Delgado Cepeda, Francisco Javier; emipsanchez; Bandala Solano, Yamir; Dulce Viridiana Melo Máximo; Rosales Hoz, María de Jesús; School of Engineering and Sciences; Campus Estado de México; González López, Vianney
Antibiotic resistance is now one of the most worrying global health threats, where common antibiotics have become obsolete. To counteract this urgent crisis, many studies and strategies have been employed to provide an effective solution. Novel therapeutic strategies have emerged, such as nanoemulsions, which offer an alternative to inhibit resistant bacteria. The application of nanoemulsions, specifically those involving essential oils, has the potential to become a constant in the industry due to their properties and capability to inhibit bacteria. Their thermoresponsive properties can make them suitable candidates to treat infections caused by resistant bacteria. This study, conducted as part of the Master of Science degree program in Nanotechnology, aims to analyze the long-lived stability of NEs and their antimicrobial properties as a possible alternative for treating microorganisms that exhibit antibiotic resistance. Hysteresis and thermoresponsive characterization of the NEs is a relevant aspect to ensure the stability of the NEs at possible operational conditions and thus the preservation of the antimicrobial properties of the NE. Finally, computational models will be employed as an approach to understand droplet formation and behavior.
Observer-based controller for unmanned aerial vehicles in reforestation applications
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2024-05-28) Muñoz Sepúlveda, Gustavo Alberto; Lozoya, Rafael Camilo; emimmayorquin; Castañeda, Herman; School of Engineering and Sciences; Campus Monterrey; Abaunza, Hernán
This study presents a breakthrough in unmanned aerial vehicle (UAV) technology, showcas- ing the efficacy of a custom-designed controller and observer in the context of reforestation initiatives. Through meticulous experimentation and analysis, the study demonstrates the ob- server’s adeptness in mitigating external disturbances, thereby enhancing the precision and stability of UAV operations. This technological advancement not only holds promise for diverse practical applications but also holds profound implications for environmental con- servation efforts, particularly reforestation. Reforestation plays a pivotal role in mitigating climate change, preserving biodiversity, and safeguarding ecosystems. By leveraging UAV technology, this study propels forward the efficacy and efficiency of reforestation endeavors, laying the groundwork for future innovations in UAV-based interventions. The findings affirm the viability of the proposed controller and observer framework, highlighting its potential to revolutionize environmental monitoring, conservation, and sustainable resource management practices. This abstract encapsulates the significance of integrating cutting-edge technology with environmental conservation efforts, underscoring the pivotal role of UAVs in fostering a more sustainable future.
In silico Design and Analysis of Stability Parameters of Asymmetrical Liposomes
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2023-06-15) Núñez García, Eduardo; Montes Fonseca, Silvia Lorena; emimmayorquin; Oseguera Guerra, Berenice Erendira; School of Bioengineering and Sciences; Campus Monterrey; Flores Holguin, Norma
Asymmetric liposomes are vesicles that can be assembled from different lipids compositions to improve specific characteristics for each leaflet of the liposome, depending on the intended use. However, the characterization of these nanosystems at an experimental level is complex. The use of MD simulations, and specifically CG models as the Martini force field, allows the design and analysis of these lipidic nanostructures to be faster and cheaper experimentally. Despite the innovation and constant development of MD simulations, this tool has not yet been used as a method to evaluate multiple lipid compositions for asymmetric liposomes, which led to this study, where the design and analysis of multiple asymmetric bilayers and vesicles containing DOTAP, DOPE, DSPC, and cholesterol were created through the INSANE and BUMPy scripts for further evaluation of their structure and stability by measuring their bilayer thicknesses, APL, SASA, gyration radius, and cholesterol positioning. All simulated structures remained stable for 3 microseconds and showed different behaviors depending on their composition, especially cholesterol content that strongly affected the structures' characteristics, meaning that the Martini CG model can be used to determine characteristics of interest in the analysis of multiple liposomal compositions. Based on the analysis made of the bilayers and vesicles during this work, bilayers’ compositions DOTMA:DOPE 1:1, DOTMA:DOPE:Cholesterol 1:1:1, and 5:3:0.4 had the best properties to remain stable over time, and vesicle’s composition DOTMA:DOPE:Cholesterol 1:1:1 presented more satisfactory results overall. Further analysis of the vesicle might be beneficial for a better understanding of the composition. The proposed work serves as a first approach to use MD simulations as a tool to be applied in the decision-making process for developing drug delivery carriers in experimental laboratories, reducing economic and time restrictions.

Ciencias Exactas y Ciencias de la Salud

Browse

Filters

Settings

Sort By

Results per page

Search Results