Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551039
Pertenecen a esta colección Tesis y Trabajos de grado de las Maestrías correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
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- High-density coaxial emitter device for electrospray: pushing the limits of additively manufactured microfluidic devices by SLA/DLP(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2022-06) Lozano Sura, Roberto Carlos; Olvera Trejo, Daniel; emimmayorquin; Escuela de Ingeniería y Ciencias; Campus MonterreyPhotopolymerization-based 3D printing technologies like SLA and DLP offer efficient fabrication of diverse structures, eliminating the requirement for molds or machining. These techniques allow fast fabrication of intricate designs such as microfluidics devices at low cost, however, the accuracy and resolution of microchannels are still challenging to control for very intricate microfluidics. This study focuses on understanding the influence of manufacturing parameters on the quality of microchannels and miniaturization limits by developing a mathematical model to predict mechanical properties depending on the curing times. Also, we study the limits of this technology in terms of the accuracy of microchannels for the fabrication of multiplexed coaxial electrospray sources. We demonstrate the effectiveness of the mathematical model to improve the quality of these devices with diameters of 360 um with 41 unclogged coaxial nozzles in 1 cm2. The contribution of this work also demonstrated incorporating purge channels was essential to clean uncured resin and the proposed procedure to ensure proper cleaning of the device. The devices were electrically characterized via electrospray processes observing uniform array operation depending on the nozzle size.
- New Generation of 3D printed electrospray sources for microencapsulation in biomedical applications(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2018-05-14) Benjamin de Jesus, Benjamín Evani; Zúñiga, Alex Elías; Olivera Trejo, Daniel; Martínez Romero, Oscar; García López, ErikaAdditive manufacturing by Digital Light Processor stereolithography (DLP-SLA) has shown a great potential to create high-density microfluidic devices due to it offers high resolution and relatively low-cost. In this work, the fabrication of 3D printed coaxial electrospray sources with a high density of emitters are reported by using DLP-SLA technology. The 3D printed electrospray sources have also proven to work correctly as a source of microencapsulation. To accomplish the objectives of the study, it was addressed in three sections primarily. First, the influence of the involved parameters on the final properties of printed microchannels was evaluated by the analysis and characterization of this promising additive manufacturing technology. Second, based on its maximum printing capabilities, multiplexed electrospray sources were designed. To manufacture suitable channels with diameters up to 160 µm, it was key to establish the smallest dimensions of the new devices, which were successfully printed with 41 and 57 coaxial emitters respectively. Finally, Vitamin D and alginate hydrogel were used to produce core-shell microparticles as an initial exploration in the encapsulation of biomedical substances via coaxial electrospraying. The accurate encapsulation was dependent on the flow rate, applied voltages, and mainly on the concentration of alginate solution.