Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551039
Pertenecen a esta colección Tesis y Trabajos de grado de las Maestrías correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
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- Design and fabrication of transdermal microneedle inserts by Stereolithography for Ultrasonic Injection Molding(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2020-12-08) Villa Carrillo, Karla Marcela; Vázquez Lepe, Elisa Virginia; tolmquevedo; García López, Erika; Rodríguez González, Ciro Angel; School of Engineering and Sciences; Campus Monterrey; Martínez López, José IsraelIn this work design of a transdermal microneedle patches with hexagonal and squared cross-sections are explored using stereolithography for manufacturing ultrasonic injection molding inserts. A multi-cavity mold was designed using Finite Element Method based software, where polypropylene injection molding simulations were performed for design optimization. Manufacture of the proposed device was assessed using a stereolithography based additive manufacturing equipment suitable for high temperature applications. Dimensional accuracy was evaluated using three-dimensional metrology. Deviational height errors of 18.05% and 39.21% were found for the hexagonal and square microneedle insert cavities. A successful proof-of-concept ultrasonic injection molding is a step forward for manufacturing of microneedles for the point-of-care.
- Evaluation of the dimensional capabilities for the technologies of selective laser melting and digital light processing, to fabricate microcavities: microneedle insert as case of study.(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2020-06-16) Meneses Ricaurte, Cindy Paola; Vázquez Lepe, Elisa Virginia; emipsanchez/tolmquevedo; Sandoval Robles, Jesús Alejandro; Rodríguez González, Ciro Ángel; School of Engineering and Sciences; Campus Monterrey; García López, ErikaAdditive manufacturing technologies are nowadays a feasible resource in micro parts fabrication, which have a wide range of applications from medical industry to injection molding. These technologies allow fabrication of complex parts with a variety of geometries and sizes that ultimately gives a competitive advantage by letting the manufacturing of insert molds. This research study the dimensional capabilities of selective laser melting and digital light processing to produce microneedle cavities from 500 μm to 2500 μm. An insert for microneedle was manufactured variating its bases geometries and successfully fabricated through selective laser melting at 0°, 45° and 90° orientations. Similarly, for the digital light processing technology, inserts for microneedle geometries were manufactured at 0° and 45° build surface orientation. It was found for the hexagonal base geometry, the best for both technologies with the lower dimensional errors, due to a common factor between processes called stair steeping. By using a reduction in border and contour power, height dimensional accuracy of the microneedle insert was improved. There was a minimum error of 3% for 600 μm of nominal height corresponding to the fabricated insert by selective laser melting at 0°orientation of construction with the optimal design.