Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551039
Pertenecen a esta colección Tesis y Trabajos de grado de las Maestrías correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
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- Drug delivery dynamics of biopolymer-protein based nanostructures cues via experimental approach and mathematical modeling(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2022-06-07) Ibarra Sánchez, Luis Ángel; IQBAL, HAFIZ MUHAMMAD NASIR; 735340; Nasir Iqbal, Hafiz Muhammad; emipsanchez; Parra Saldívar, Roberto; Melchor Martínez, Elda Madai; Gámez Méndez, Ana María; School of Engineering and Sciences; Campus Monterrey; Sosa Hernández, Juan EduardoRespiratory diseases are leading the burden in public health, usually found in the top chart of leading causes of death for many countries. Moreover, COVID-19 has aggravated this situation, having numerous patients with mild to severe symptoms. Besides, lung tissue inflammation and mucus overproduction are critical factors in patients’ comorbidity, not only for COVID-19 but also in other pulmonary diseases. In this project, the aim was to integrate the natural therapeutics curcumin (with a studied anti-inflammatory effect) and papain (a proteolytic enzyme used for mucus degradation) into a drug delivery nanostructure to administer intranasally. To reach this goal, curcumin was encapsulated in alginate particles with the emulsion-gelation method, obtaining an encapsulation efficiency of 81.23%. Also, curcumin particles showed a mean size of 500.8 nm, and a surface charge of -23.5 mV. Nonetheless, more studies are required to fully understand the emulsion system to obtain smaller and less disperse particles. Also, bioavailability and efficacy test are required to confirm feasibility of the project. In summary, nanoencapsulation in alginate via emulsion-gelation method has shown promising results for enhancing the curcumin solubility, bioavailability, and stability, to develop more efficient pulmonary treatments against inflammation.
- Valorization of pelagic Sargassum as a source of alginate and sugars for subsequent biofuel production(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2021-11-01) Amador Castro, Luis Fernando; Carrillo Nieves, Danay; puemcuervo; García Cayuela, Tomás; Guajardo Flores, Daniel; School of Engineering and Sciences; Campus Monterrey; Rodríguez Martínez, VerónicaOver the last decade, massive tides of Sargassum, a genus of brown algae, have arrived at Caribbean shores deriving in a myriad of environmental and economic problems. Aiming to lessen the impacts, governments from the affected countries have opted to remove the seaweed from marine ecosystems. However, its collection is expensive, posing another economic challenge for the already affected countries. Biomass valorization has been proposed as a suitable alternative to funding cleaning activities, triggering numerous investigations in recent years. Albeit different pathways have been suggested, Sargassum biomass has failed to find effective uses in the industry. This study aims to maximize the value of Sargassum as a potential raw material into a biorefinery scheme to produce alginate and sugars, considering this last product for subsequent biofuels production. Findings indicate that alginate extraction and sugar production can be effectively coupled within the same valorization scheme and that their integration also results in sugar maximization after biological pretreatment. The alginate extraction and purification process resulted in high polymer yields (38.75% ± 0.93 dry weight). The final product was found to be free of toxic elements opening the doors for its application in different fields. Lastly, Sargassum sugars extracts did not inhibit the growth of Yarrowia lipolytica, an oleaginous yeast, suggesting that they can be subsequently converted into biofuels.
- Electrohydrodynamic encapsulation of probiotics in heat-resistant mMicrocapsules for applications in the food industry(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2020-06) Toro Galárraga, David Alejandro; OLVERA TREJO, DANIEL; 269684; Olvera Trejo, Daniel; RR; Soría Hernández, Cintya Geovanna; Elías Zúñiga, Alex; School of Engineering and Sciences; Campus Monterrey; Martinez Romero, OscarProbiotics are an important part of functional foods and are defined as living microorganisms that confer health benefits to the host. Viable probiotics are, however, significantly destroyed during food thermal processing and in the stomach due to harsh digestive conditions. The challenge is to improve the survival of probiotic cells during manufacture, storage, and the passage through the gastrointestinal tract of the host in order to exert their health benefits. Various microencapsulation techniques have been used to protect probiotics against harsh conditions, however, these processes have low encapsulation efficiency, low yield and high energy consumption. On the other hand, electrospray microencapsulation can be used to produce capsules ranging from the micro to the sub-micron sizes, works at room temperature and has high encapsulation efficiency with narrow particle size distribution. The objective of this project was to create heat-resistant microcapsules (HRM) via electrospraying. To accomplish this, core and shell solutions were synthesized to perform encapsulation with metallic and 3D printed electrospray sources to increase the production rate. HRMs of 394.7±44.50 μm in diameter were obtained while physicochemical characterization shows a combination of parameters of both biopolymers, which is attributed to the formation of bonds between alginate and zein in the esterification process. The thermogravimetric analysis also shows an improvement in thermal properties, reducing weight loss due to material degradation at 250 ºC from 40% to 19%. This technology is a promising technology for probiotics encapsulation and fortification of foods thermally processed.