Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551039
Pertenecen a esta colección Tesis y Trabajos de grado de las Maestrías correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
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- Simulation of protein adsorption in Ion Exchange Chromatography (IEX) with COMSOL Multiphysics(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2021-12-07) Cardoso Ortegón, Alan; IBARRA HERRERA, CELESTE CONCEPCION; 265151; Mata Gómez, Marco Arnulfo; puemcuervo; Sánchez, Mirna Lorena; Ibarra Herrera, Celeste Concepción; Cervantes Avilés, Pabel Antonio; Escuela de Ingeniería y Ciencias; Campus Puebla; Gómez Sánchez, Carlos EduardoA simulation of Ion Exchange Chromatography in COMSOL Multyphisics by the mass transport phenomena on a column with packed bed heigh of 56.52 cm. The simulation was based on the physical phenomena of convections and diffusion, both radial and axial, the chemical reaction simulated was that of Bovine serum Albumin (BSA) and recombinant Green Fluorescent Protein (rGFP) with Q Sepharose XLTM in slightly basic conditions pH 8.5. Experimental data of Langmuir Adsorption Isotherm in batch was used to determine an equilibrium constant kL and use it for the simulation reaction. Dynamic adsorption experimental data was obtained by frontal analysis of BSA and rGFP in an Äkta Pure system, that resulted in a chromatogram. The chromatogram was studied with Carta’s model to obtain physical parameters of the model proteins. The simulations were based on the experimental data and fed in several nodules of the Software to solve for a chromatographic process of adsorption through time and radial diffusion. Nodules of reaction rate of a chemical reaction (chemistry), mass transport through a system based on convection and diffusion (Transport of Dilutes Species) and for velocity vector (Darcy’s Law) were used. Coupling these nodules, the study of mass transport in a column can be visualized in 3D and the results can be plotted in a two dimensional form, this allows to plot the process in the radial direction and not only in the time dimension.
- Design, simulation and construction of a lineal induction motor for a transport application(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2020-06-15) Campoy Sousa, Angel Rodrigo; VAZQUEZ TOPETE, CARLOS RENATO; 166163; Vázquez Topete, Carlos Renato; emipsanchez; Carbajal Espinosa, Oscar Eleno; Guajardo Cuellar, Alejandro; Escuela de Ingeniería y Ciencias; Campus MonterreyThe high levels of traffic increase both the noise and air pollution in the city of Guadalajara. These affects drivers, passengers and pedestrians. The problems involved due to the current mobility system in the city motivates the research of new types of urban transport, preferably a low cost electric vehicle. An interesting option to investigate are linear induction motors (LIM), which have a low number of parts, low maintenance and low cost. In order to design a LIM, the literature about Linear Motor Design was studied in detail, specially the Equivalent Circuit Model. The model allows to dynamically simulate a LIM according to its geometrical and electrical supply specifications. In this thesis it is proposed to design, simulate and build a prototype to compare the real behavior and the results of the simulation. The vehicle should be designed to have a low cost of manufacture, have a capacity of 5-6 passengers, an average speed of 25 km/hr and a road inclination of 1.15 degrees.
- Towards a digital twin by merging discrete event simulations, augmented reality and the internet of things(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2020-06-15) Valdivia Puga, José Abraham; URBINA CORONADO, PEDRO DANIEL; 298324; Urbina Coronado, Pedro Daniel; ilquio, emipsanchez; Ahuetl Garza, Horacio; Orta Castañón, Pedro Antonio; Escuela de Ingeniería y Ciencias; Campus MonterreyThis work presents the creation and implementation of an augmented reality system to a partial digital twin for a manufacturing process through the application of discrete event simulations, IoT tools and communication protocols in an industrial environment through a mobile app presentation. This approach will take a non-connected manufacturing process and adapt it to a smart factory environment creating an intercommunicated DES system with IoT and augmented reality capabilities. This approach was achieved using a real study case which consists in a machine generating items from a percentage of the input material while the rest of the material is stored in a recovery chamber to use it again in another item creation. This process was used as an example to create a partial digital twin and implement all the tools mentioned before. This work will allow to know all the process parameters, data related to the process like cycle time, number of pieces, time per process status, etc., this information will be used to create a system in which a real-time visualization of the process and its data can be performed through the use of augmented reality tools achieved by Unity 3D software. This approach will help to create a visualization for the partial digital twin, its process and results in a real context and even allow the user to modify its conditions before their implementation through a user interface, allowing to create an infrastructure that support different scenarios, process optimizations, and know possible future conditions.