Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551039
Pertenecen a esta colección Tesis y Trabajos de grado de las Maestrías correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
Browse
Search Results
- Design and characterization of an adhesive and pH-indicating hydrogel with gentamicin release as a proof of concept for its potential use as an acute wound dressing(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2021-12-06) Viaña Mendieta, Pamela; Benavides Lozano, Jorge Alejandro; puemcuervo; Antunes Ricardo, Marilena; Mata Gómez, Marco Arnulfo; School of Engineering and Sciences; Campus Monterrey; Sánchez, Mirna LorenaWound care cost is an overwhelming problem aggravated by the burning of skin injuries and the overuse of traditional materials that are low cost-efficient. Modern wound care strives for multifunctional wound dressings to monitor physiological conditions and prevent wound infection or non-healing processes. Thus, this study addresses the synthesis and characterization of an adhesive and pH-indicating hydrogel dressing with gentamicin release for the potential acceleration and monitoring of acute wounds. The proposed hydrogels were prepared by physical and chemical crosslinking of polyvinyl alcohol (PVA), phenol red, glycerol, citric acid (CA), butyl-cyanoacrylate (BCA), and gentamicin. Diverse formulations, varying PVA and CA concentration, were evaluated and selected by the stable swelling profile. Then, the selected formulation was characterized by swelling degree, colorimetric pH-change evaluations, adhesion and dehydration assay, and drug release profile. The selected formulation was 4% wt. PVA, 5% wt. CA, 10% wt. glycerol and 1.5% wt. BCA, and showed excellent properties as a wound dressing. It had uniform transparency, a good pH-indicating property, enough water content, stable swelling degree and gentamicin release. Thus, the pH-indicating property showed the transition of pH 4 to 9, with sensitive pH change by forming the circle-like pattern at pH 8 and 9. The dehydration ratio was 1.0 and maintained adhesion to a plastic surface for 96 h. The release of gentamicin was enough in 24 h (96.3 %). Based on the results, this proof of concept concludes that the designed multifunctional hydrogel has suitable properties as a potential wound dressing. This study shows the opportunity to continue its characterization in detail in searching for a potential commercial wound dressing.
- Production and characterization of a multilayer thin film by pvd with antibacterial activity for biomedical applications(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2021) Pérez Ávila, Juana Yessica; Oseguera Peña, Joaquín Esteban; 9202; Oseguera Peña, Joaquín Esteban; emijzarate/puemcuervo; Melo Máximo, Lizbeth; School of Engineering and Sciences; Campus Estado de México; Melo Máximo, Dulce ViridianaThis thesis for the Production and Characterization of a Multilayer Thin Film by PVD with Antibacterial Activity for Biomedical Applications is for the Master’s Program in Nanotechnology at ITESM CEM. Millions of people use some form of implant in their bodies and infection is the most serious complication affecting to an important percentage of patients, causing postoperative prosthesis failure, chronic pain and immobility. This thesis aims to develop and characterize a multilayer thin film of CrN, ZnO and PEG on the substrate Ti6Al4V to be used in implants obtaining antibacterial activity and an improvement in the mechanical and morphological properties. For the deposition process, Reactive Magnetron Sputtering was used, and the characterization was performed using Optical Microscope, SEM, EDS, XRD, AFM, Nano-Indentation, Rockwell C test using VDI 3198 norm, Contact Angle, Tribometer and Colony Forming Units Counting. The results showed an improvement in the tribological characteristics and positive antibacterial action.