Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551039
Pertenecen a esta colección Tesis y Trabajos de grado de las Maestrías correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
Browse
Search Results
- CO2-derived non-isocyanate urethane based self-etching dental adhesive system(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2025-06-11) Andrade Vivanco, Alex Emilio; Beigiboroujeni, Saeed; emipsanchez; Salinas Salazar, Carmen Lizzeth; Montesinos Castellanos, Alejandro; Bonilla Cruz, José; School of Engineering and Sciences; Campus Monterrey; Yeganeh, HamidThis study reports the synthesis and comprehensive evaluation of a novel maleated self-etch urethane monomer (MAUM) designed to enhance dental adhesive performance. Adhesive formulations containing 0–25 phr MAUM were assessed for polymerization kinetics, mechanical properties, etching efficacy, bonding strength, water sorption, and cytotoxicity. Photo-DSC and FTIR analyses revealed that methacrylate conversion increased from 76% to 89% with MAUM addition, despite a 25% decrease in total polymerization enthalpy, attributed to the maleate groups’ lower reactivity and delayed vitrification from flexible side chains. Mechanical testing showed that fracture toughness improved by up to 40% at 20 phr MAUM, while flexural strength (109–130 MPa) and modulus (2250–2690 MPa) remained statistically unchanged. SEM imaging confirmed ductile fracture surfaces and effective etching of enamel and dentin, facilitating hybrid layer formation. Microshear bond strength (μSBS) increased significantly from 5.68 MPa (5% MAUM) to 15.49 MPa (20% MAUM), matching the commercial adhesive benchmark (15.76 MPa). Water sorption measurements showed a reduction from 30.2 μg/mm³ in the control to 24.5 μg/mm³ in 20 phr MAUM adhesives, indicating improved hydrolytic stability. Cytotoxicity tests with L929 fibroblasts demonstrated >85% cell viability for both 0 phr and 20 phr formulations, surpassing commercial adhesives that often fall below 60% viability. Collectively, these results demonstrate that MAUM enhances polymer network quality, mechanical resilience, adhesive performance, and biocompatibility, while reducing water uptake, supporting its promise for durable and safe dental adhesives.
- Design and characterization of an adhesive and pH-indicating hydrogel with gentamicin release as a proof of concept for its potential use as an acute wound dressing(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2021-12-06) Viaña Mendieta, Pamela; Benavides Lozano, Jorge Alejandro; puemcuervo; Antunes Ricardo, Marilena; Mata Gómez, Marco Arnulfo; School of Engineering and Sciences; Campus Monterrey; Sánchez, Mirna LorenaWound care cost is an overwhelming problem aggravated by the burning of skin injuries and the overuse of traditional materials that are low cost-efficient. Modern wound care strives for multifunctional wound dressings to monitor physiological conditions and prevent wound infection or non-healing processes. Thus, this study addresses the synthesis and characterization of an adhesive and pH-indicating hydrogel dressing with gentamicin release for the potential acceleration and monitoring of acute wounds. The proposed hydrogels were prepared by physical and chemical crosslinking of polyvinyl alcohol (PVA), phenol red, glycerol, citric acid (CA), butyl-cyanoacrylate (BCA), and gentamicin. Diverse formulations, varying PVA and CA concentration, were evaluated and selected by the stable swelling profile. Then, the selected formulation was characterized by swelling degree, colorimetric pH-change evaluations, adhesion and dehydration assay, and drug release profile. The selected formulation was 4% wt. PVA, 5% wt. CA, 10% wt. glycerol and 1.5% wt. BCA, and showed excellent properties as a wound dressing. It had uniform transparency, a good pH-indicating property, enough water content, stable swelling degree and gentamicin release. Thus, the pH-indicating property showed the transition of pH 4 to 9, with sensitive pH change by forming the circle-like pattern at pH 8 and 9. The dehydration ratio was 1.0 and maintained adhesion to a plastic surface for 96 h. The release of gentamicin was enough in 24 h (96.3 %). Based on the results, this proof of concept concludes that the designed multifunctional hydrogel has suitable properties as a potential wound dressing. This study shows the opportunity to continue its characterization in detail in searching for a potential commercial wound dressing.