Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551039
Pertenecen a esta colección Tesis y Trabajos de grado de las Maestrías correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
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- Applying a competitive technology intelligence methodology for avocado seed analysis: trends and applications(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2024) González López, Héctor Andrés; Rodríguez Salvador, Marisela; emimmayorquin; Hernández Brenes, Carmen; Chuck Hernández, Cristina; Campus MonterreyThe avocado fruit is among the world's most cultivated crops due to increasing market demand. According to FAOSTAT (2021), annual global production reached 8.69 million tons in 2021. The pulp is the primary product of interest, and avocado processing results in 2.42 million tons of byproducts, mainly seeds and peels, constituting around 30% of the weight (Araújo et al., 2018). Despite their valuable biochemical properties and potential applications, avocado seeds are often overlooked and discarded. This thesis employs a Competitive Technology Intelligence (CTI) methodology to uncover trends and applications through scientific literature and patent analysis. A query was developed through iterative expert feedback, and data published between January 1, 2019, and December 31, 2023, was collected from major scientific and patent databases. After rigorous deduplication and manual verification, 278 scientific publications and 228 patents were analyzed. The scientific publications were categorized into areas such as Agricultural Applications, Environmental Applications, Health Applications, and Industrial Applications. Each of these categories was further divided into multiple subcategories to provide deeper insights. In contrast, patents were categorized into areas that reflect their unique aspects and applications, such as Cosmetic and Personal Care Applications, Environmental and Sustainable Technologies, Equipment and Devices, among others. This research highlighted notable progress in the use of avocado seeds across various sectors, including pharmaceuticals, cosmetics, bioenergy, pollution control, materials development, and food and packaging products. The countries with the most academic and scientific publications were Mexico, Brazil, Indonesia, Nigeria, Colombia, and India. The intellectual property offices with the most published patents were the China National Intellectual Property Administration (CNIPA), the World Intellectual Property Organization (WIPO), the Korean Intellectual Property Office (KIPO), and the United States Patent and Trademark Office (USPTO). This research highlights the potential of avocado seeds as a multifunctional resource that can contribute to economic growth while addressing environmental challenges. The findings aim to support and guide Research and Development activities in businesses and academic institutions regarding investment in technologies that harness the value of avocado seeds, potentially leading to sustainable industry practices and innovative product development.
- Applying competitive technology intelligence to reveal advances in final end user applications, user acceptability, quality assurance, and digital technologies of 3D printing for oral drug delivery systems(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2023-06-12) Ríos Mata, Verónica Lissette; Rodríguez Salvador, Marisela; puemcuervo, emimayorquin; Smith Cornejo, Neale Ricardo; Bourguet Díaz, Rafael Ernesto; School of Engineering and Sciences; Campus MonterreyThe demands for high-value innovative treatments, investment in Research and Development (R&D), and personalized medicines are shaping the pharmaceutical industry, for this, current manufacturing methods may not be able to satisfy these needs. Three-dimensional printing offers different solutions for specific needs that cannot be attended due to the high cost of production, limitations on the process, or individualized demands. 3D printing oral drug delivery systems enhance the delivery of a pharmaceutical substances in the body and the dynamics between pharmaceutical ingredients, while providing personalized formulation, geometry, size, controlled release rate and time on the gastrointestinal tract. On the other hand, for a company to stay relevant in the market, it should be able to develop and integrate a sustainable differentiation, also known as a long-term competitive advantage (Porter, M., 1996). This competitive advantage can be based on the introduction and acquisition of new technologies. The process of identifying market opportunities, trends and new technologies is not always direct, for this, Competitive Technology Intelligence methodology and Scientometric analysis are utilized to reveal technological knowledge and technologies, in order to identify trends that can be turned into actionable information. The aim of this thesis is to use Competitive Technology Intelligence (CTI) methodology to reveal advances in Final End User Applications, User Acceptability, Quality Assurance, and Digital Technologies of 3D Printing for Oral Drug Delivery Systems and facilitate decision-making to stakeholders, upper management, firms or people belonging to the pharmaceutical, medical, healthcare and 3D printing area. Using a query developed from the CTI methodology a total of 621 papers from 01-01-1900 to 05-01-2023, after the database cleaning process the number of results decreased to 512. The 512 publications were categorized into 9 classifications, where the 149 corresponding to the categories Final End User Applications, User Acceptability, Quality Assurance, and Digital Technologies were analyzed. The results demonstrated a tendency towards digitalization of the industry, that looks forward to migrating clinical trials to digital solutions. Machine Learning is being used to optimize and predict parameters of the process and the behavior of the formulations. Applications like DEFEND3D are being examined to avoid the cyber risks of remote digital transfer of electronic prescriptions to the 3D printer. Quality assurance is one of the main concerns while developing 3D printed oral drug delivery systems. Quality by Design (QbD) approach is being used to efficient the design of a product. At the same time, protocols to standardize compounding procedures (mixing, preparation, and printing) as well as decision maps to facilitate decision-making of the pharmacist are being developed. The integration of all these methods can lead to quality assurance in the different types of dosage forms. In the Final End User application trend, abuse-deterrent 3D printed oral dosage forms are being designed to limit the accessibility to non-prescribed opioids, as a solution to the opioid abuse world crisis. For disease treatment, 3D printed capsules that permit the intake of multiple drugs and avoid the negative interactions between active pharmaceutical ingredients are being developed. User preferences and palatability are also being taken into consideration while designing 3D printed dosage forms, as it can facilitate their entry to the market.
- Using Competitive Technology Intelligence to Determine Potato Peel Upcycling Trends and Applications(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2022-11-20) Fox Miranda, Itzel; TEJADA ORTIGOZA, VIRIDIANA ALEJANDRA; 420889; Rodríguez Salvador, Marisela; emipsanchez; Tejada Ortigoza, Viridiana Alejandra; Hernández Brenes, Carmen; School of Engineering and Sciences; Campus MonterreyIn the potato processing industry, specifically in potato chip manufacturing, potato peel is one of the main byproducts. Potato peel needs to be treated and managed properly to prevent environmental damage and promote economic growth through its use by innovating traditional processes, technologies, and products. In this context, Competitive Technology Intelligence (CTI) is a tool that provides relevant knowledge to support decision-making and strategic planning, that can create value in potato peel processing. For this reason, this thesis applied a CTI methodology using scientometric, patentometric, and product market analysis to reveal scientific and technological developments in potato peel byproduct. A Global Query was developed by an iterative process with expert feedback to retrieve scientific documents and published patents from renowned databases, published from January 1st, 2018, to April 30th, 2023. After deduplication and a manual verification process, 393 scientific publications and 82 published patents were collected. The publications were manually classified based on the publication focus in three main categories: Application, Process, and Economic Analysis. The growth kinetics, top journals and countries, and number of citations were determined. Market information was gathered from renowned databases and customer needs, industry development, and potato peel products on the market were identified. Potato peel identified applications were as a substrate, adsorbent, biopolymer, antioxidant, agriculture component, animal and insect feed, and functional ingredient. The main processing techniques were bioactive compounds and biopolymers extraction and pretreatment. The most prolific countries from scientific documents were India, Egypt, and China, and the intellectual property (IP) offices with the most published patents were China National Intellectual Property Administration, World Intellectual Property Organization, and Intellectual Property India. Potato peel research publication rate was affected by global COVID-19 pandemic. Furthermore, consumers desire to lower their environmental impact and need products that are plastic-free, benefit their health, and help them to adapt to harsh weather conditions. In addition, there is a need to promote the term upcycle since many consumers are not familiarized with it, and the ones who do relate it with reducing waste.
- 4d printing research trends and applications in the medical field: a scientometric analysis(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2022-07-28) Padilla Aguirre, Karen Marcela; RODRIGUEZ SALVADOR, MARISELA; 20562; Rodríguez Salvador, Marisela; emijzarate, emipsanchez; Urbina Coronado, Pedro Daniel; Elizondo Noriega, Armando; Escuela de Ingeniería y Ciencias; Campus MonterreyInnovation plays a key role on a company’s either success or failure. But innovation is not just the creating or adopting new technologies; it is also directly connected with a solid strategic planning. Competitive technology intelligence is based on the systematic and ethical process of gathering, analyzing and transforming information into actionable knowledge. It aims to support decision making and strategic planning, because the knowledge produced by this methodology constitutes an early warning for research, development and innovation [19]. Three-dimensional (3D) printing is a technique of additive manufacturing that has revolutionized engineering, product design and manufacturing, as it allows the rapid conversion of digital 3D model information into physical static objects [45]. However, in the last few years a new possibility has been introduced to add ’time’ as a new dimension to create 4D printing. The medical field keeps changing and progressing at a high speed with new technologies emerging every day. 4D printing on the medical field is an area where it is necessary to provide decision makers with an overview of technological knowledge that helps them generate innovation opportunities. On this thesis, a Competitive technology intelligence approach was executed to identify trends in 4D printing technologies applied to the medical field, in order to provide relevant information through a technological landscape to support decision makers to uncover innovation opportunities. The results of the analysis revealed that most of the research developed is on the materials category, which relates completely to the fact that smart materials are the key difference between 3D and 4D printing. Most of the researches focus on shape memory polymers, hydrogels and liquid crystal elastomers. On the processes category researched is focused on the physical configuration of the printing model, printing parameters and adapting machines to modify the printing configurations. As for the applications, three main subcategories were identified, hollow tubes/stents, tissue engineering and drug delivery. According to the growth kinetics it is a field that although is fairly new, keeps growing and will keep gaining attention.