Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551039
Pertenecen a esta colección Tesis y Trabajos de grado de las Maestrías correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
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- Exploring the research landscape of 3D printing in oral drug delivery systems for central nervous system diseases(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2025-06-10) Paipa Jabre Cantú, Samir Ibrahim; Rodríguez Salvador, Marisela; emimmayorquin; Tercero Gómez, Víctor Gustavo; School of Engineering and Sciences; Campus Monterrey; Zhang, Y. ShrikeThe pharmaceutical industry faces increasing demands for innovative and personalized treatments that conventional manufacturing methods often struggle to meet. Three-dimensional printing (3DP) offers tailored solutions through customized oral drug delivery systems, enabling precise control over dosage, geometry, release kinetics, and gastrointestinal absorption—factors especially critical in therapies for central nervous system (CNS) disorders. This study applies a Competitive Technology Intelligence (CTI) approach to analyze advancements in 3DP for oral drug delivery, with a focus on Fused Deposition Modeling (FDM), Semi-Solid Extrusion (SSE), Stereolithography (SLA), Digital Light Processing (DLP), Selective Laser Sintering (SLS), and Binder Jetting (BJ). FDM emerges as the most widely used technique due to its cost-effectiveness and versatility for thermostable drugs (e.g., carbamazepine), while SSE proves optimal for thermolabile compounds (e.g., levetiracetam) due to its room-temperature operation. SLA and DLP enable complex geometries for controlled release, and BJ supports scalable production, exemplified by the commercial formulation Spritam®. Key findings highlight patient-centric applications such as pediatric-friendly formulations (e.g., flavored orodispersible films), geriatric-adapted designs (e.g., easy-to-swallow tablets), and accessible formats for patients with disabilities (e.g.,Braille-marked pills). Current challenges include limitations in printable materials (e.g., polymer compatibility) and the lack of regulatory standardization. By mapping these technologies and their therapeutic implications, this thesis offersactionable insights for stakeholders in the pharmaceutical, healthcare, and 3DP sectors to support the development of personalized dosing strategies, combination therapies, and improved treatment adherence in CNS care.
- Applying a competitive technology intelligence methodology for avocado seed analysis: trends and applications(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2024) González López, Héctor Andrés; Rodríguez Salvador, Marisela; emimmayorquin; Hernández Brenes, Carmen; Chuck Hernández, Cristina; Campus MonterreyThe avocado fruit is among the world's most cultivated crops due to increasing market demand. According to FAOSTAT (2021), annual global production reached 8.69 million tons in 2021. The pulp is the primary product of interest, and avocado processing results in 2.42 million tons of byproducts, mainly seeds and peels, constituting around 30% of the weight (Araújo et al., 2018). Despite their valuable biochemical properties and potential applications, avocado seeds are often overlooked and discarded. This thesis employs a Competitive Technology Intelligence (CTI) methodology to uncover trends and applications through scientific literature and patent analysis. A query was developed through iterative expert feedback, and data published between January 1, 2019, and December 31, 2023, was collected from major scientific and patent databases. After rigorous deduplication and manual verification, 278 scientific publications and 228 patents were analyzed. The scientific publications were categorized into areas such as Agricultural Applications, Environmental Applications, Health Applications, and Industrial Applications. Each of these categories was further divided into multiple subcategories to provide deeper insights. In contrast, patents were categorized into areas that reflect their unique aspects and applications, such as Cosmetic and Personal Care Applications, Environmental and Sustainable Technologies, Equipment and Devices, among others. This research highlighted notable progress in the use of avocado seeds across various sectors, including pharmaceuticals, cosmetics, bioenergy, pollution control, materials development, and food and packaging products. The countries with the most academic and scientific publications were Mexico, Brazil, Indonesia, Nigeria, Colombia, and India. The intellectual property offices with the most published patents were the China National Intellectual Property Administration (CNIPA), the World Intellectual Property Organization (WIPO), the Korean Intellectual Property Office (KIPO), and the United States Patent and Trademark Office (USPTO). This research highlights the potential of avocado seeds as a multifunctional resource that can contribute to economic growth while addressing environmental challenges. The findings aim to support and guide Research and Development activities in businesses and academic institutions regarding investment in technologies that harness the value of avocado seeds, potentially leading to sustainable industry practices and innovative product development.
- Applying competitive technology intelligence to reveal advances in final end user applications, user acceptability, quality assurance, and digital technologies of 3D printing for oral drug delivery systems(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2023-06-12) Ríos Mata, Verónica Lissette; Rodríguez Salvador, Marisela; puemcuervo, emimayorquin; Smith Cornejo, Neale Ricardo; Bourguet Díaz, Rafael Ernesto; School of Engineering and Sciences; Campus MonterreyThe demands for high-value innovative treatments, investment in Research and Development (R&D), and personalized medicines are shaping the pharmaceutical industry, for this, current manufacturing methods may not be able to satisfy these needs. Three-dimensional printing offers different solutions for specific needs that cannot be attended due to the high cost of production, limitations on the process, or individualized demands. 3D printing oral drug delivery systems enhance the delivery of a pharmaceutical substances in the body and the dynamics between pharmaceutical ingredients, while providing personalized formulation, geometry, size, controlled release rate and time on the gastrointestinal tract. On the other hand, for a company to stay relevant in the market, it should be able to develop and integrate a sustainable differentiation, also known as a long-term competitive advantage (Porter, M., 1996). This competitive advantage can be based on the introduction and acquisition of new technologies. The process of identifying market opportunities, trends and new technologies is not always direct, for this, Competitive Technology Intelligence methodology and Scientometric analysis are utilized to reveal technological knowledge and technologies, in order to identify trends that can be turned into actionable information. The aim of this thesis is to use Competitive Technology Intelligence (CTI) methodology to reveal advances in Final End User Applications, User Acceptability, Quality Assurance, and Digital Technologies of 3D Printing for Oral Drug Delivery Systems and facilitate decision-making to stakeholders, upper management, firms or people belonging to the pharmaceutical, medical, healthcare and 3D printing area. Using a query developed from the CTI methodology a total of 621 papers from 01-01-1900 to 05-01-2023, after the database cleaning process the number of results decreased to 512. The 512 publications were categorized into 9 classifications, where the 149 corresponding to the categories Final End User Applications, User Acceptability, Quality Assurance, and Digital Technologies were analyzed. The results demonstrated a tendency towards digitalization of the industry, that looks forward to migrating clinical trials to digital solutions. Machine Learning is being used to optimize and predict parameters of the process and the behavior of the formulations. Applications like DEFEND3D are being examined to avoid the cyber risks of remote digital transfer of electronic prescriptions to the 3D printer. Quality assurance is one of the main concerns while developing 3D printed oral drug delivery systems. Quality by Design (QbD) approach is being used to efficient the design of a product. At the same time, protocols to standardize compounding procedures (mixing, preparation, and printing) as well as decision maps to facilitate decision-making of the pharmacist are being developed. The integration of all these methods can lead to quality assurance in the different types of dosage forms. In the Final End User application trend, abuse-deterrent 3D printed oral dosage forms are being designed to limit the accessibility to non-prescribed opioids, as a solution to the opioid abuse world crisis. For disease treatment, 3D printed capsules that permit the intake of multiple drugs and avoid the negative interactions between active pharmaceutical ingredients are being developed. User preferences and palatability are also being taken into consideration while designing 3D printed dosage forms, as it can facilitate their entry to the market.
- Using competitive and technology intelligence to determine 4D printing technology advances in health considering design factors and applications.(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2023-05) Martínez de Anda, Angelica Anette; RODRIGUEZ SALVADOR, MARISELA; 20562; Rodríguez Salvador, Marisela; puemcuervo, emipsanchez; Bourguet Díaz, Rafael Ernesto; Smith Cornejo, Neale Ricardo; School of Engineering and Sciences; Campus MonterreyCurrently there is an increasing demand in the medical field for low-cost, high-quality products as well as personalized solutions, and different manufacturing methods are being investigated to provide innovative solutions. Four-dimensional (4D) printing is a promising technology to solve challenges associated with applications of 4D printing in regenerative medicine and biomedical devices. A revolution is expected to come in this regard, and it is essential to keep abreast of the latest developments. Under this context, the purpose of this thesis is to determine 4D printing technology advances in the medical field, considering design factors and applications, using a Competitive Technology Intelligence (CTI) methodology. For this aim, publications were analyzed from the Scopus database between January 1, 2017, and May 9, 2023. The main trends were identified for both Design Factors and Applications. In the first case, the following were considered: 4D printing methods, external stimuli, materials, mathematical models, interaction mechanisms, and deformation mismatch, while in the second case, the applications of 4D printing involved were considered: drug delivery systems, stents, and scaffolds. The obtained Design Factors results included improvements in mechanical properties of hydrogels by adding magnetic nanoparticles, bio-polyurethan, and other materials, the development of cell-friendly bioprinting methods to print cellular structures, and the use of theoretical-experimental approaches to predict shape deformation of structures. While for Applications, results included advances in the development of expandable drug delivery systems, fabrication of stents for treatment of vascular and tracheal stenosis, and the design of scaffolds for the treatment of cartilage defects and bone regeneration. This research contributes to researchers, academics, and companies involved in Research and Development (R&D) and Innovation looking for new solutions to improve health incorporating breakthrough technologies such as 4D printing.
- Using Competitive Technology Intelligence to Determine Potato Peel Upcycling Trends and Applications(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2022-11-20) Fox Miranda, Itzel; TEJADA ORTIGOZA, VIRIDIANA ALEJANDRA; 420889; Rodríguez Salvador, Marisela; emipsanchez; Tejada Ortigoza, Viridiana Alejandra; Hernández Brenes, Carmen; School of Engineering and Sciences; Campus MonterreyIn the potato processing industry, specifically in potato chip manufacturing, potato peel is one of the main byproducts. Potato peel needs to be treated and managed properly to prevent environmental damage and promote economic growth through its use by innovating traditional processes, technologies, and products. In this context, Competitive Technology Intelligence (CTI) is a tool that provides relevant knowledge to support decision-making and strategic planning, that can create value in potato peel processing. For this reason, this thesis applied a CTI methodology using scientometric, patentometric, and product market analysis to reveal scientific and technological developments in potato peel byproduct. A Global Query was developed by an iterative process with expert feedback to retrieve scientific documents and published patents from renowned databases, published from January 1st, 2018, to April 30th, 2023. After deduplication and a manual verification process, 393 scientific publications and 82 published patents were collected. The publications were manually classified based on the publication focus in three main categories: Application, Process, and Economic Analysis. The growth kinetics, top journals and countries, and number of citations were determined. Market information was gathered from renowned databases and customer needs, industry development, and potato peel products on the market were identified. Potato peel identified applications were as a substrate, adsorbent, biopolymer, antioxidant, agriculture component, animal and insect feed, and functional ingredient. The main processing techniques were bioactive compounds and biopolymers extraction and pretreatment. The most prolific countries from scientific documents were India, Egypt, and China, and the intellectual property (IP) offices with the most published patents were China National Intellectual Property Administration, World Intellectual Property Organization, and Intellectual Property India. Potato peel research publication rate was affected by global COVID-19 pandemic. Furthermore, consumers desire to lower their environmental impact and need products that are plastic-free, benefit their health, and help them to adapt to harsh weather conditions. In addition, there is a need to promote the term upcycle since many consumers are not familiarized with it, and the ones who do relate it with reducing waste.
- 4d printing research trends and applications in the medical field: a scientometric analysis(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2022-07-28) Padilla Aguirre, Karen Marcela; RODRIGUEZ SALVADOR, MARISELA; 20562; Rodríguez Salvador, Marisela; emijzarate, emipsanchez; Urbina Coronado, Pedro Daniel; Elizondo Noriega, Armando; Escuela de Ingeniería y Ciencias; Campus MonterreyInnovation plays a key role on a company’s either success or failure. But innovation is not just the creating or adopting new technologies; it is also directly connected with a solid strategic planning. Competitive technology intelligence is based on the systematic and ethical process of gathering, analyzing and transforming information into actionable knowledge. It aims to support decision making and strategic planning, because the knowledge produced by this methodology constitutes an early warning for research, development and innovation [19]. Three-dimensional (3D) printing is a technique of additive manufacturing that has revolutionized engineering, product design and manufacturing, as it allows the rapid conversion of digital 3D model information into physical static objects [45]. However, in the last few years a new possibility has been introduced to add ’time’ as a new dimension to create 4D printing. The medical field keeps changing and progressing at a high speed with new technologies emerging every day. 4D printing on the medical field is an area where it is necessary to provide decision makers with an overview of technological knowledge that helps them generate innovation opportunities. On this thesis, a Competitive technology intelligence approach was executed to identify trends in 4D printing technologies applied to the medical field, in order to provide relevant information through a technological landscape to support decision makers to uncover innovation opportunities. The results of the analysis revealed that most of the research developed is on the materials category, which relates completely to the fact that smart materials are the key difference between 3D and 4D printing. Most of the researches focus on shape memory polymers, hydrogels and liquid crystal elastomers. On the processes category researched is focused on the physical configuration of the printing model, printing parameters and adapting machines to modify the printing configurations. As for the applications, three main subcategories were identified, hollow tubes/stents, tissue engineering and drug delivery. According to the growth kinetics it is a field that although is fairly new, keeps growing and will keep gaining attention.
- Revealing a knowledge landscape on sustainable alternatives for plastic materials in takeaway food packaging(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2021-12-03) Oviedo González, María Marcela; RODRIGUEZ SALVADOR, MARISELA; 20562; Rodríguez Salvador, Marisela; puemcuervo; Takeda Toda, Naoko; Muñiz Rivera, Gerardo; School of Engineering and Sciences; Campus MonterreyPlastics have been among the most commonly used materials for food packaging solutions, especially in the takeaway sector because of their convenient features such as flexibility, low cost of production, their durability and most importantly they keep their edible contents safe and in a good state (British Plastics Federation, 2021). Nevertheless, in the last decade, as the use of plastics in takeaway food packaging has risen, the amount of waste and pollution has created a negative impact on the environment (Takeaway Packaging, 2021). The purpose of this thesis will focus on revealing sustainable alternatives for plastic materials in takeaway food packaging, to generate a knowledge landscape for decision making. The application of Competitive and Technology Intelligence (Rodriguez- Salvador, et.al., 2017) strategically evaluates science and technology to reveal the current global trends as well as the most prolific countries and organizations to obtain opportunities for innovation, while enabling the inclusion of diverse analytical methods to enrich the information analysis process. Thus, the Design Futures’ Design Fiction (Kelleher & Byrne, 2015) approach was incorporated in this process to better understand the situations behind the research foci, creating speculation on how the future of alternatives for plastic materials in takeaway food packaging applications could preferably be and how it might be attainable, facilitating the decision-making process. The information resources for this thesis were scientific publication records from SCOPUS and Web of Science database platforms that ran from Jan. 1st, 2017, to Nov. 5th, 2021. A sub-categorization of sustainable alternatives to plastic materials in takeaway food packaging was made to perform a thorough search: “Paper & Cardboard”, “Metals”, “Natural Fibers” and “Biodegradable Polymers”. These are the current material solutions available on the market. Competitive and Technology Intelligence revealed the current global trends on sustainable alternatives for plastics in takeaway food packaging as well as the most prolific countries and organizations in terms of developing scientific research. China and Malaysia are the top publication countries. Educational Institutions are leading the research on sustainable material alternatives for plastics, The Universiti Putra Malaysia (Malaysia) is the top affiliation with most published articles in this field. Experts interviewed agreed that the sole practice of replacing plastic materials in single-use takeaway food packaging is not enough to tackle the current plastic pollution problem, as a recycling culture needs to be practiced at home, “users who consume food packaging and do not discard it properly are the problem”. The utilization of the Design Fiction scope through the employment of the Affinity Diagram by Design Futures’ Contextual Design Fiction (Holtzblatt K. & Beyer H., 2014), helped to better understand the situations behind the research foci for the 4 sub-categories and to create speculation on how the future of sustainable alternatives for plastic materials in takeaway food packaging applications could preferably be and how it might be attainable. It also helped to imagine undesirable future pathways as a way of avoiding failure in the near future by addressing the information obtained from research through Competitive and Technology Intelligence. Long-term sustainability must assess the elimination of waste products and the integration into the circular economy to comply with regulations set by the European Union, which will represent a pivotal decision-making asset to consider when launching new sustainable alternatives to plastic food packaging solutions on the market. Further assessments on the disposal behaviors within society should be made, as well as takeaway food packaging needs to lengthen the time they are used rather than being disposed. The findings of this thesis help the decision-making process of food industry stakeholders and R&D to support initiatives and applications of alternatives for takeaway food packing. The strategic vision obtained from the Competitive Technology Intelligence-Design Fiction approach can be further explored by researchers as a guide to reveal advances in other areas of study.
- Application of competitive technology intelligence on HVAC systems for green buildings(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2020-12-01) Benavides Reyes, Victor Manuel; RODRIGUEZ SALVADOR, MARISELA; 20562; Rodríguez Salvador, Marisela; qrotbecerra/puemcuervo; Romero Díaz, David Carlos; Ugalde Hernández, Alan; School of Engineering and Sciences; Campus Monterrey; Morales Menéndez, RubénDuring the last two decades, Heating, Ventilation, and Air Conditioning (HVAC) power consumption have been approximately 50% of the total utilized in the building and construction sector, which equivalent to 10-20% of the total energy consumed worldwide (Perez-Lombard et al., 2011). The global need to optimize operation costs, save energy, and develop more sustainable offices, is driving the development of new technology trends with more sustainable and climate benefits. These trends are generating new codes and regulations applied to these areas, where federal agencies and municipalities offer economic incentives that make investments in green buildings more attractive. The objective of this thesis is to explore existing technology trends focused on energy efficiency, indoor air quality, ventilation, and sustainability, using a Competitive Technology Intelligence (CTI) methodology to identify the key drivers on energy consumption and discover opportunities to innovate towards more efficient systems. This methodology provides insight into opportunity areas such as integrated systems design and innovation in software that allows better flexibility in maintaining the required energy, air management, comfort levels, indoor air quality, and sustainability. Energy demand on HVAC systems varies according to season and climate zone; depending on design and configuration, different applications in several cases might reach up to 21% annual energy savings (Vakiloroaya et al., 2014). Based on a study on cost analysis and technical evaluations, the return of investment values for HVAC systems applications might oscillate between 2 -11 years (in the best scenario) in terms of energy consumption benefits (Marino & Minichiello, 2015). They also may have other benefits, such as the possibility of using renewable energy sources, improving indoor air quality, creating a clean and healthy environment, and low CO2 emissions.
- Propuesta de Integración de la Inteligencia Competitiva y Tecnológica con el Kansei Engineering en el Diseño de Estufas de Inducción Magnética-Edición Única(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2010-12-01) Moreno Chávez, Stephanie M.; Rodríguez Salvador, Marisela; Serna Vázquez, Livier; Loera Hernández, Imelda; Tecnológico de Monterrey, Campus Monterrey; Mayeux, JamesLas líneas para futuras investigaciones en el camp o de la Inteligencia Competitiva son amplias, profundizadas por el hecho de que cad a vez las empresas utilizan más tecnología y las aprovechan de diferentes formas. Actualmente, existen una serie de metodologías y herramientas que son útiles en la aplicación de la Inteligencia Competitiva sin embargo, es necesario ampliar los campos de aplicaciones y lograr su institucionalización dentro de las organizaciones, no solo de México, sino del mundo en general. En el área de Diseño del Producto las emociones del usuario proveen información sobre el objeto que debe estar presente en el Proceso de Diseño com o atributos de diseño involucrados en el producto, a través del Kansei Engineering. En el presente trabajo de tesis se propone un metodología que integra la Inteligencia Competitiva y Tecnológica con el Kansei Engineering para desarrollar y diseñar productos basados en las emociones y sentimientos del usuario.
- Propuesta de integración de la inteligencia competitiva con la innovación abierta: aplicación en la industria de mantenimiento de aviones comerciales(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2010-12-01) Vega Pino, José Roberto Antonio; VEGA PINO, JOSÉ ROBERTO ANTONIO; 296906; Rodríguez Salvador, Marisela; Güemes Castorena, David; Bourguet Díaz, Rafael; Tecnológico de Monterrey, Campus Monterrey; Smith Cornejo, Neale RicardoLa competencia se vuelve cada vez más compleja por lo que ya no es suficiente competir con los recursos que actualmente poseen las empresas, siendo necesario recurrir a la utilización del talento externo. Es en este caso que se deberán establecer conexiones con agentes o grupos externos que contribuyan a brindar nuevas soluciones a los problemas. En base a este requerimiento, en la presente investigación se propone una metodología que integra la Inteligencia Competitiva con la Innovación Abierta para establecer conexiones entre grupos externos y la empresa de acuerdo a las necesidades del mercado. Con lo cual se busca desarrollar proyectos estratégicos que analicen efectivamente el entorno (con la Inteligencia Competitiva) favoreciendo la interacción entre agentes internos y externos a la empresa (con la Innovación Abierta). La metodología propuesta cuenta con una Fase Estratégica, una Operativa y una de Resultados, desglosadas en varios pasos. La validez de la metodología propuesta se comprueba a través de su aplicación en un proyecto de expansión de una empresa Latinoamericana de mantenimiento de aviones comerciales. El proyecto cuenta con un enfoque estratégico que considera la detección de clientes potenciales dentro de 5 a 10 años. Dentro de este análisis se tomará en cuenta la atractividad de mercados potenciales, proveedores, clientes y amenazas futuras del entorno.