Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551039
Pertenecen a esta colección Tesis y Trabajos de grado de las Maestrías correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
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- Design for manufacturing and assembly of a multi material bioprinting system towards tissue engineering applications(2025-06-13) Lera Julián, Miguel Ángel; Martínez López, José Israel; emipsanchez; Vázquez Lepe, Elisa Virginia; López Botello, Omar; Chuck Hernández, Cristina; School of Engineering and Sciences; Campus MonterreyLight-based techniques have great potential in bioprinting for tissue engineering, given their inherent advantages in high spatial resolution (10–100 μm) and improved cell viability (>85%) compared to traditional extrusion-based systems. However, current apparatuses found in the state of the art are limited in usability and functionality due to legacy single-material design constraints and the early development stage of photopolymerization-based bioprinters. As tissue constructs become increasingly complex, there is a need to establish a new framework for light-based equipment tailored to specific tissue engineering applications. This work presents the development of multi-material bioprinting equipment that integrates 4K digital light projection with an automated rotating four-vat system, enabling sequential use of bioinks with distinct mechanical and biochemical properties. For this endeavor, the scalability and manufacturability of the apparatus were addressed using Function Tree analysis, Quality Function Deployment (QFD), and Design for Manufacturing and Assembly (DFM&A) principles. These tools guided the definition of a feature set for meniscal tissue regeneration, including layered constructs with stiffness gradients and bioactive cues. The system was designed in Fusion and fabricated using a combination of rapid prototyping techniques. This included the 3D printing of custom resin vats, CNC machining of structural elements, and the development of bespoke electronic components for control and actuation. Initial validation was carried out using a single-vat configuration and Anycubic clear photopolymer resin. Printing trials demonstrated the resolution capacity of the optical system and successful layer-by-layer polymerization using 405 nm light exposure. These results confirm the operational feasibility of the system and establish a baseline for future multi-material implementation using photocurable bioinks
- Manufacturing of three-dimensional micromixers using additive manufacturing and non-conventional processes(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2023-12) Yáñez Espinosa, Christian Rodrigo; Martínez López, José Israel; emipsanchez; Vázquez Lepe, Elisa Virginia; García López, Erika; School of Engineering and Sciences; Campus MonterreyThis work explores strategies for manufacturing complex three-dimensional micromixers by using unconventional technologies such as stereolithography (SLA), lost-wax casting, and pyrolysis. The employment of these technologies is assessed towards the development of a new generation of methodologies enabled by advanced manufacturing that includes features to integrate micromixing on devices for medical and environmental applications. Three different technologies were studied to evaluate the potential to improve the flexibility and resolution of devices designed to stir and mix reagents within systems where mass transfer is limited by laminar flow regimes. For this work, the state-of-the-art manufacturing for micromixing devices was investigated, and then experimental assessment of the potential technologies was evaluated for a novel helicoidal micromixer design. Insights of the current state of manufacturing for microdevices were carried out using computational fluid dynamics to evaluate the potential of recent technologies compared with more conventional manufacturing technologies.