Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551039
Pertenecen a esta colección Tesis y Trabajos de grado de las Maestrías correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
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- Auxiliary method based on effective medium theory for biosensing applications using surface plasmon resonance(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2020-05) Balderas Elizalde, Alejandro; Hernández Aranda, Raúl Ignacio; lagdtorre/tolmquevedo; Ornelas Soto, Nancy; Pérez García, Benjamín; Escuela de Ingeniería y Ciencias; Campus Monterrey; Morales Luna, GesuriIn this thesis, an auxiliary method based on the effective medium theory is applied to surface plasmon resonance (SPR) biosensing in order to extract quantitative properties of the biosensor functionalization. An automatized SPR biosensor array was built to perform intensity measurements in an automatized and controlled manner. Five gold layers with different Bovine Serum Albumin (BSA) deposition times were measured in the sensor and the refractive index and thickness of the sample were both estimated using the gradient descent method in combination of a theoretical model. These parameters were then introduced into two distinct effective medium theories in order to change a qualitative description of the surface coverage into a quantitative one. Yielding values of 30 % for the linear effective field approximation (EFA) and 50 % for the non-linear Quasicrystalline Approximation (QCA). Finally, a qualitative detection of a BSA-Carbamazapine (CBZ) was done utilizing the sensor in which there is a significant difference in the response of the sensor compared to the one of bare gold and BSA.
- Thickness measurement and optical characterization of dielectric thin-films using surface plasmon resonance(2017-05-16) Orejel Orejel, Robin; Hernández Aranda, Raúl Ignacio; García Ortíz, César Eduardo; Cortés Martínez, Rodolfo; López Mago, DoriliánIn this thesis we present a method to determine the thickness of dielectric thin films (<100 nm). The thickness of four magnesium-fluoride (MgF2) thin films of different thicknesses is accurately determined by detecting the angle at which surface plasmon resonance (SPR) occurs. The experiment consists of the measurement of the attenuated total internal reflection using an optical setup based on the Kretschmann configuration. Curves from a theoretical model for multilayer thin film resonance are used to fit the experimental results in order to obtain the dielectric film thickness. Additionally, we calculated numerically the dispersion relation for an insulator-insulator-metal-insulator (IIMI) structure and determined the experimental range of parameters where the system is the most sensitive.