Ciencias Exactas y Ciencias de la Salud

Permanent URI for this collectionhttps://hdl.handle.net/11285/551039

Pertenecen a esta colección Tesis y Trabajos de grado de las Maestrías correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.

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Advisor: search.filters.advisor.Guajardo Flores, DanielSubject: search.filters.subject.Acne vulgaris

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    Tesis de maestría / master thesis
    In vitro evaluation of delivery systems integrating huauzontle (Chenopodium berlandieri) extracts with anti-inflammatory and antioxidant properties for their potential use in the cosmetic industry
    (Instituto Tecnológico y de Estudios Superiores de Monterrey, 2022-05-25) Mejía Valdez, Daniel Eduardo; Guajardo Flores, Daniel; puemcuervo, emimayorquin; Antunes Ricardo, Marilena; School of Engineering and Sciences; Campus Monterrey; Martínez Ávila, Mariana
    Chenopodium berlandieri spp. (Huauzontle) is a Mexico-native pseudocereal with interesting compounds. It is considered a traditional food crop since prehispanic times, and it is still consumed as a fresh or cooked vegetable. Its enhanced nutritional properties of bioactive compounds, such as saponins and oleanolic acid, are giving it the attention of scientists. Here, we propose the development of a liposome delivery system integrating an extract and a hydrolyzed extract from huauzontle for their potential use in the cosmetic industry. Conventional solid/liquid extraction will be performed to obtain saponin-rich extracts, and through HPLC-ELSD and LC-MS/TOF, their characterization will be carried out. Once characterized, the extract will be hydrolyzed in order to obtain oleanolic acid, which is also intended to be integrated into a liposome delivery system. Finally, to measure the efficacy of the liposomes, the biological activities of dermatological importance for androgenic alopecia, acne vulgaris, and skin wrinkling will be tested. We expect to observe particle sizes of the liposome delivery system below 200 nm, necessary for a correct permeability of the skin; additionally, we expect to achieve good biological activities to prevent and treat stated skin conditions; those expected results are crucial to deem the introduction of these delivery system loaded with huauzontle extracts for their potential use in the cosmeceutical industry.
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