2018-10-192018-10-192314613310.1155/2015/285491http://hdl.handle.net/11285/630675The aim of this study was to investigate the relationship between functional polymorphisms Gly482Ser in PPARGC1A and Pro12Ala in PPARG2 with the presence of obesity and metabolic risk factors. We included 375 individuals characterized as Mexican-Mestizos and classified by the body mass index (BMI). Body dimensions and distribution of body fat were measured. The HOMA-IR and adiposity indexes were calculated. Adipokines and metabolic profile quantification were performed by ELISA and routine methods. Genetic polymorphisms were determined by polymerase chain reaction restriction fragment length polymorphism analysis. A difference between obese and nonobese subjects in polymorphism PPARGC1A distribution was observed. Among obese individuals, carriers of genotype 482Gly/Gly were observed to have decreased body fat, BMI, and body fat ratio versus 482Ser/Ser carriers and increased resistin and leptin levels in carriers Gly+ phenotype versus Gly- phenotype. Subjects with PPARG2 Ala- phenotype (genotype 12Pro/Pro) showed a decreased HOMA-IR index versus individuals with Ala+ phenotype (genotypes 12Pro/Ala plus 12Ala/Ala). We propose that, in obese Mexican-Mestizos, the combination of alleles 482Ser in PPARGC1A and 12Pro in PPARG2 represents a reduced metabolic risk profile, even when the adiposity indexes are increased. © 2015 Mónica Vázquez-Del Mercado et al.info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0adipocytokineapolipoprotein A1apolipoprotein Bglucosehigh density lipoprotein cholesterolinsulinleptinlow density lipoprotein cholesterolperoxisome proliferator activated receptor gamma 2peroxisome proliferator activated receptor gamma coactivator 1alpharesistintriacylglycerolvery low density lipoprotein cholesterolgenetic markerperoxisome proliferator activated receptor gammaperoxisome proliferator activated receptor gamma coactivator 1alphaPPARGC1A protein, humantranscription factorabdominal obesityadipogenesisadultalleleArticlebody fatbody masscontrolled studydyslipidemiafemalegenetic polymorphismgenetic riskglucose metabolismhip circumferencehumanmajor clinical studymaleMestizoMexicanobesityphenotypepolymerase chain reactionrestriction fragment length polymorphismwaist circumferenceage distributionagedalleleethnologygenetic association studygenetic markergenetic predispositiongeneticsincidenceMetabolic DiseasesMexicomiddle agedobesityrisk factorsex ratiosingle nucleotide polymorphismvery elderlyyoung adultAdultAge DistributionAgedAged, 80 and overAllelesFemaleGenetic Association StudiesGenetic MarkersGenetic Predisposition to DiseaseHumansIncidenceMaleMetabolic DiseasesMexicoMiddle AgedObesityPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPolymorphism, Single NucleotidePPAR gammaRisk FactorsSex DistributionTranscription FactorsYoung Adult7 INGENIERÍA Y TECNOLOGÍAArtículo2015