Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults

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dc.creatorElena Cristina González Castillo
dc.creatorBianca Daniela Nieblas León
dc.creatorCarlos Eduardo Rodríguez López
dc.creatorGerardo de Jesús García Rivas
dc.creatorLuz Leticia Elizondo Montemayor
dc.date2017
dc.date.accessioned2018-10-18T20:34:54Z
dc.date.available2018-10-18T20:34:54Z
dc.descriptionVitamin D deficiency is present even in sunny regions. Ageing decreases pre-vitamin D production in the skin and is associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, and inflammatory markers according to seasonal variation in Mexican healthy older adults. The same cohort was followed during 12 months. Vitamin D deficiency/insufficiency was found in 91.3% of the subjects despite living in appropriate latitude (25°40′0″N). 25(OH)D levels remained below <30 ng/mL through all seasons. Vitamin D deficiency did not correlate to sun exposure or dietary intake. Gender was the strongest associated factor, explaining a variance of 20%. Waist circumference (WC) greater than 88 cm was a risk factor for vitamin D deficiency. Age (>74 years) combined with WC (>88 cm) and BMI (>32.7) showed a high probability (90%) of vitamin D deficiency. Remarkably, an increase in one centimeter in WC decreased 25(OH)D by 0.176 ng/mL, while an increase in one point BMI decreased 25(OH)D by 0.534 ng/mL. A cutoff point of 74 years of age determined probability of vitamin D hipovitaminosis. Vitamin D deficiency was correlated with TNF-α serum levels, possibly increasing the susceptibility of older adults to a proinflammatory state and its related diseases. © 2017 Leticia Elizondo-Montemayor et al.
dc.identifier.doi10.1155/2017/5719461
dc.identifier.issn9629351
dc.identifier.urihttp://hdl.handle.net/11285/630391
dc.identifier.volume2017
dc.languageeng
dc.publisherHindawi Limited
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85030669020&doi=10.1155%2f2017%2f5719461&partnerID=40&md5=2e2efc4bbbee0be261c9f1f4610b4fe2
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceMediators of Inflammation
dc.subject25 hydroxyvitamin D
dc.subjectcytokine
dc.subjectgamma interferon
dc.subjectinterleukin 10
dc.subjectinterleukin 12p70
dc.subjectinterleukin 17
dc.subjectinterleukin 1beta
dc.subjectinterleukin 23
dc.subjectinterleukin 33
dc.subjectinterleukin 6
dc.subjectinterleukin 8
dc.subjectmonocyte chemotactic protein 1
dc.subjecttumor necrosis factor
dc.subjectvitamin D
dc.subjectadult
dc.subjectage
dc.subjectaged
dc.subjectanthropometric parameters
dc.subjectArticle
dc.subjectdietary intake
dc.subjectfemale
dc.subjecthuman
dc.subjectinflammation
dc.subjectlatitude
dc.subjectlifestyle
dc.subjectlongitudinal study
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmultivariate analysis
dc.subjectprobability
dc.subjectrisk assessment
dc.subjectseasonal variation
dc.subjectsex difference
dc.subjectsun exposure
dc.subjectvitamin D deficiency
dc.subjectwaist circumference
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleSeasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults
dc.typeArtículo
refterms.dateFOA2018-10-18T20:34:54Z

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