Regulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals

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dc.creatorNiria Treviño Saldaña
dc.creatorGerardo de Jesús García Rivas
dc.date2017
dc.date.accessioned2018-10-19T14:22:13Z
dc.date.available2018-10-19T14:22:13Z
dc.descriptionModulation of posttranslational modifications (PTMs), such as protein acetylation, is considered a novel therapeutic strategy to combat the development and progression of cardiovascular diseases. Protein hyperacetylation is associated with the development of numerous cardiovascular diseases, including atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. In addition, decreased expression and activity of the deacetylases Sirt1, Sirt3, and Sirt6 have been linked to the development and progression of cardiac dysfunction. Several phytochemicals exert cardioprotective effects by regulating protein acetylation levels. These effects are mainly exerted via activation of Sirt1 and Sirt3 and inhibition of acetyltransferases. Numerous studies support a cardioprotective role for sirtuin activators (e.g., resveratrol), as well as other emerging modulators of protein acetylation, including curcumin, honokiol, oroxilyn A, quercetin, epigallocatechin-3-gallate, bakuchiol, tyrosol, and berberine. Studies also point to a cardioprotective role for various nonaromatic molecules, such as docosahexaenoic acid, alpha-lipoic acid, sulforaphane, and caffeic acid ethanolamide. Here, we review the vast evidence from the bench to the clinical setting for the potential cardioprotective roles of various phytochemicals in the modulation of sirtuin-mediated deacetylation. © 2017 Niria Treviño-Saldaña and Gerardo García-Rivas.
dc.identifier.doi10.1155/2017/1750306
dc.identifier.issn19420900
dc.identifier.urihttp://hdl.handle.net/11285/630658
dc.identifier.volume2017
dc.languageeng
dc.publisherHindawi Limited
dc.relationhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85040682445&doi=10.1155%2f2017%2f1750306&partnerID=40&md5=d8f685bb2a7213266f48c40e6c3c7f73
dc.relationInvestigadores
dc.relationEstudiantes
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0
dc.sourceOxidative Medicine and Cellular Longevity
dc.subjectCardiology
dc.subjectDiseases
dc.subjectModulation
dc.subjectProteins
dc.subjectAcetyltransferases
dc.subjectCardiac hypertrophy
dc.subjectCardio-vascular disease
dc.subjectCardioprotective effect
dc.subjectDocosahexaenoic acid
dc.subjectEpigallocatechin-3-gallate
dc.subjectPost-translational modifications
dc.subjectTherapeutic strategy
dc.subjectAcetylation
dc.subjectacyltransferase
dc.subjectbakuchiol
dc.subjectberberine
dc.subjectcaffeic acid
dc.subjectcurcumin
dc.subjectdocosahexaenoic acid
dc.subjectepigallocatechin gallate
dc.subjectethanolamide
dc.subjecthonokiol
dc.subjectoroxilyn a
dc.subjectphenol derivative
dc.subjectphytochemical
dc.subjectquercetin
dc.subjectresveratrol
dc.subjectsirtuin
dc.subjectsirtuin 1
dc.subjectsirtuin 3
dc.subjectsulforaphane
dc.subjectthioctic acid
dc.subjecttyrosol
dc.subjectunclassified drug
dc.subjectcardiotoxicity
dc.subjectcardiovascular disease
dc.subjectdrug bioavailability
dc.subjectenzyme inhibition
dc.subjectheart protection
dc.subjecthuman
dc.subjectnonhuman
dc.subjectprotein acetylation
dc.subjectprotein function
dc.subjectReview
dc.subjectAcetylation
dc.subjectDiseases
dc.subjectProteins
dc.subject.classification7 INGENIERÍA Y TECNOLOGÍA
dc.titleRegulation of Sirtuin-Mediated Protein Deacetylation by Cardioprotective Phytochemicals
dc.typeArtículo
refterms.dateFOA2018-10-19T14:22:13Z

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