Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551014
Pertenecen a esta colección Tesis y Trabajos de grado de los Doctorados correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
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- Effect of the parametrization of the gyroid curvature over the collective cell organization(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2024-05) Flores Jiménez, Mariana Sofía; Fuentes Aguilar, Rita Quetziquel; emipsanchez; Trujillo de Santiago, Grissel; Barocio Vaca, Eduardo; Chairez Oria, Jorge Isaac; Perfecto Avalos, Yocanxochitl; School of Engineering and Sciences; Campus Guadalajara; García González, AlejandroThe collective cell organization is important for different physiological processes, as the formation of epithelial structures, wound healing and cancer metastasis. However, the influence of the curvature that surrounds them has been mostly studied in cylindrical, spherical, and sinusoidal surfaces, while hyperbolic geometries have been overlooked, even though they are present in several structures, as in bone trabeculae, and vascular networks. In this work, wells with the shape of the gyroid surface were fabricated by two methods, 3D extrusion bioprinting, and by silicon mold casting, in order to assess the effect of the gyroid curvature parameters in different material stiffness. It was found that the substrate stiffness effect is predominant over curvature parameters variation, since cells were generally rounder in softer materials, while a collective detachment was present in stiffer substrates.
- Showcase of mechatronic methodology for the design and manufacturing of implantable medical devices(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2023-06-19) Vázquez Armendáriz, Javier Oswaldo; VAZQUEZ ARMENDARIZ, JAVIER OSWALDO; 851762; Rodríguez González, Ciro Ángel; puemcuervo, emipsanchez; García López, Erika; Vázquez Lepe, Elisa Virginia; López Botello, Omar Eduardo; School of Engineering and Sciences; Campus Monterrey; Dean, DavidMechatronics is a multidisciplinary area that enables the integration of mechanical, electronic and control theory for the design of cutting-edge products or advanced manufacturing systems. For decades, it has been combined with other areas, such as medicine for the design and manufacture of implants, thanks to the development of rapid prototyping technologies (e. g., 3D printing) and conventional manufacturing methods. In order to contribute to the development of novel medical therapies while pushing the boundaries of personalized implant manufacturing, this thesis showcases the approach of the mechatronic V-model as design methodology to support the implantable device development cycle. The development and fabrication methods for three implantable products was addressed: (1) fabrication of scaffolds for regenerative medicine and tissue engineering (TE) applications manufactured by Fused Deposition Modeling (FDM), (2) fabrication of thin, personalized cell-thick membranes using the novel Melt Electrowriting (MEW) technique, and (3) the robotic Point-of-Care Manufacturing (POCM) of fixation hardware for craniomaxillofacial (CMF) procedures. The developed technology for each implant introduced specific research questions, challenges, and contributions for each manufacturing method (e. g., FDM, MEW and POCM). In addition, the contributions converged in the publication of high-impact research papers, the presentation of findings at international and relevant conferences for medical devices, the disclosure of intellectual property and international collaboration. Despite the promising results obtained so far, we continue working on technological maturation and regulatory validation in order to translate our innovations into the medical practice.