Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551014
Pertenecen a esta colección Tesis y Trabajos de grado de los Doctorados correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
Browse
Search Results
- Development of a competitive technology intelligence methodology to identify technology dynamics: the case of M-health for diabetes(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2024-11-13) Castillo Valdez, Pedro Fernando; Rodríguez Salvador, Marisela; emipsanchez; Martínez Ledesma, Emmanuel; Díaz de la Garza, Rocío Isabel; Hernánez Brenes, Carmen; Tejeda Alejandre, Raquel; School of Engineering and Sciences; Rectoría Tec de MonterreyThe unprecedented development of technological advances brings new challenges and opportunities to create competitive advantages. It is necessary the effective use of technology as a facilitator to bring better products and services in all sectors such as industry, business, education, healthcare, and government. An adequate assessment of science and technology is fundamental to impact present and future Research and Development (R&D) and innovation decisions. Diverse disciplines based on metrics analysis have emerged to facilitate science and technology understanding, such as scientometrics, patentometrics, and altmetrics. They offer fundamental theoretical and methodological contributions to quantify scientific research literature, patents, scholarly activities on social networks and websites, aiming to reveal the process of scientific and technology development. However, the current accelerated technological advances require researchers to implement a superior approach to detect continuous changes in the external environment identifying opportunities and vulnerabilities to strengthen the decision-making process regarding R&D and innovation. Organizations can increase their advantages by systematically analyzing the external environment, identify movements of competitors and detect opportunities for growth. In this context, Competitive Technology Intelligence (CTI) offers a strategic approach where information is transformed into opportunities for an actionable result. This research proposes a CTI methodology of eight steps that incorporates experts feedback, a scientometrics and a word distribution analysis into a process to provide a broader scope to science and technology. This thesis provides a more robust analytical approach than traditional scientometric analysis where indicators as relevant authors, institutions, countries, citations, and impactful articles are identified. In this context, this thesis goes further since current hotspots and landscape of main research topics are also determined as well as technological trends, gaps, and opportunity areas to research, evolving the traditional scientometric approach. To demonstrate the methodology proposed, a case study was carried out around diabetes m-Health which is particularly relevant given the worldwide increase in diabetes prevalence. Identifying its technological dynamics can facilitate the adoption of effective technologies that enhance patients' quality of life. As a result of all this process, three scientific publications were developed and published in Q1, and Q2 journals. In the first publication (2021) the proposed CTI methodology is VII presented, while in the second publication (2024) the methodology is applied through a scientometric analysis where current hotspots on diabetes m-Health are determined. Finally, the third publication (2024) provides a landscape of main research topics in diabetes m-Health, and technological trends and opportunity areas to research are identified. These studies aim to contribute researchers, decision makers, and policy makers to prioritize R&D efforts, consolidate areas of interest and explore new research topics.
- Study of secondary metabolites, microRNAs, and antidiabetic properties from the medicinal plant Murraya koenigii(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2023-05-31) Gutiérrez García, Claudia; GUTIERREZ GARCIA, CLAUDIA; 460587; Sharma, Ashutosh; emipsanchez; Paul, Sujay; Molina Aguilar, Christian; Díaz Muñoz, Mauricio; Paola Isabel, Angulo Bejarano; Escuela de Ingeniería y Ciencias; Campus MonterreyMurraya koenigii is a medicinal plant that grows in Asia and is distributed throughout India; however, it can also grow in Mexico. This plant is one of the few species that produce carbazole alkaloids which are therapeutic compounds with great commercial value. Traditionally, this plant is used to treat gastrointestinal disorders, inflammation, and diabetes, among other ailments. The plant's pharmacological properties are mainly attributed to its secondary metabolites, whose production depends mostly on its grown environmental conditions. Currently, only a few compounds have been identified; nevertheless, there is a lack of a secondary metabolites profile of the grown-in-Mexico M. koenigii. Additionally, the production of these compounds can be regulated post-transcriptionally by small non-coding RNA molecules called microRNAs (miRNAs). However, in the literature, there is no information available about its miRNA profile nor its implications in the synthesis of secondary metabolites. Additionally, diabetes mellitus is a metabolic disorder that affects more than 10 % of the world population and there is an urgent need for alternative treatments such as medicinal plants. Therefore, this project aimed to annotate the secondary metabolites profile of grown-in-Mexico M. koenigii and to reveal the microRNAs involved in their synthesis as well as to evaluate its in vivo antidiabetic potential. In the present study, 268 new compounds were tentatively identified from the methanolic extract of the leaves of grown-in-Mexico M. koenigii. Moreover, 142 conserved and 7 novel miRNAs were found, along with their target enzyme genes implicated in the terpenoid backbone and the flavonoid biosynthesis pathways. Also, this research project revealed that there was no significant decrease in blood glucose in M. koenigii-treated diabetic groups compared to the control group, but there was a decreasing tendency. Finally, miRNAs knowledge could improve the genetic engineering research to produce pharmaceutic and commercial secondary metabolites from M. koenigii, and further studies are suggested to continue investigating and validating its phytochemical content and its pharmacological properties.
- Evaluation of Hydrogel Materials for Insulin Delivery in Closed Loop Treatment of Diabetes Mellitus(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2008-01-01) Sánchez Chávez, Irma Yolanda; SANCHEZ CHAVEZ, IRMA YOLANDA; 254442; Francisco Ángel Bello; Dr. Sergio Omar Martínez Chapa; Dr. Nicholas A. Peppas; Dr. Hugo Alberto Barera Saldaña; Dr. Blanca Hazalia Lapizco Encinas; Dr. Rubén Morales MenéndezThe recovery of diminished or lost regulatory functions of physiological systems drives important research efforts in biomaterials and modeling and control engineering. Special interest is paid to diabetes mellitus because of its epidemic dimensions. Hydr