Ciencias Exactas y Ciencias de la Salud
Permanent URI for this collectionhttps://hdl.handle.net/11285/551014
Pertenecen a esta colección Tesis y Trabajos de grado de los Doctorados correspondientes a las Escuelas de Ingeniería y Ciencias así como a Medicina y Ciencias de la Salud.
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- PLA coating technologies for next-generation coronary stents: dip coating, spray coating, and electrospinning(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2025-06-12) Macías Naranjo, Mariana; Vázquez Lepe, Elisa Virginia; emipsanchez; Rodríguez González, Ciro Ángel; Sánchez Domínguez, Margarita; Tejeda Alejandre, Raquel; Vázquez Armendáriz, Javier Oswaldo; School of Engineering and Sciences; Campus Monterrey; García López, ErikaCurrently, various diseases are caused by the occlusion of ducts in the body. One of the most common and recurring solutions is the implantation of stents. This surgical intervention, called angioplasty, involves placing a stent in a blocked vessel to restore blood flow. Although early-generation stents made of metallic alloys, such as stainless steel (SS), demonstrated excellent mechanical properties, they are not biodegradable and often lead to long-term complications, including neointimal proliferation and chronic inflammation. As a result, polymeric coatings have been introduced to improve biocompatibility and serve as drug reservoirs. However, challenges remain in achieving optimal surface properties, such as uniformity, low roughness, and controlled thickness, which are critical for stent performance and hemocompatibility. This thesis examines three polymer coating techniques—dip coating, spray coating, and electrospinning—and assesses their effectiveness in meeting these requirements. The first article investigates dip coating using stainless steel (SS) substrates and evaluates the impact of process parameters on coating uniformity, roughness, and thickness. The second article introduces electrospinning as a method to create nanofibrous PLA coatings on SS stents, highlighting those process parameters involved in the impact of fiber diameter and surface coverage. The third article extends this approach to magnesium-based stents (WE43 alloy), addressing the additional requirement of controlling degradation rates for biodegradable applications. The last article focuses on spray coating, examining how variations in flow rate, spraying time, spraying distance, rotational speed, and inlet air pressure influence coating morphology. Altogether, this research provides a comprehensive evaluation of coating technologies for next-generation coronary stents, aiming to optimize surface characteristics to improve biocompatibility, mechanical performance, and degradation control.
- Solid-phase-extraction of tamoxifen and its major metabolites from human-blood-plasma using electrospun polyacrylonitrile/metal-organic-frameworks nanocomposites for potential applications in breast cancer hormonal therapy monitoring.(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2023-11-01) Flores Hernandez, Domingo Ricardo; Bonilla Rios, Jaime; emimmayorquin; Hernández Hernández, José Ascención; Lozano Sánchez, Luis Marcelo; Boriskina, Svetlana; Escuela de Ingeniería y Ciencias; Campus Monterrey; Sánchez Fernández, José AntonioBreast cancer is a major public health concern with a high level of mortality. Tamoxifen hormonal therapy has been shown to reduce the risk of recurrence and improve survival outcomes in certain types of breast cancer. Despite its effectiveness, not all breast cancer patients are eligible for or benefit from tamoxifen therapy. Moreover, tamoxifen is associated with potential side effects, such as blood clots and uterine cancer. Therefore, decisions regarding the use of tamoxifen should be based on a careful assessment of individual risk-benefit profiles. It has been found that Tamoxifen is a prodrug that produces Endoxifen and 4-hydroxitamoxifen, which are more pharmacologically active. Moreover, there is a relation between endoxifen levels in the blood and the effectiveness of Tamoxifen therapy. Typically, these metabolites are monitored using High Performance Liquid Chromatography coupled with tandem Mass Spectrometry (HPLC-Ms/Ms), which is expensive, requires specialized technical expertise, and might be less accessible for some healthcare facilities. In this research are designed and manufactured a series of solid-phase extractors (SPE) using electrospun nano-fibers containing several Metal-Organic-Frameworks (MOFs). The MOF's high porosity, tunable functionality, and structural diversity, along with the electrospun fibers high surface area and mechanical strength, are promising chromatographic tools. The nano-composed SPE were studied from the theoretical perspective as well as a comprehensive characterization to determine their selectivity, specificity, sensitivity, and stability towards Tamoxifen, Endoxifen, N-desmethyl tamoxifen, and 4-hydroxitamoxifen.