Ciencias Exactas y Ciencias de la Salud

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Controlled drug delivery strategies: Advances on the synthesis and molecular dynamics of dendrimers, and optimization of liposomes preparation by Dual Asymmetric Centrifugation
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2017-12-01) Sampogna Mireles, Diana; SAMPOGNA MIRELES, DIANA; 386013; Valencia Gallegos, Jesús Ángel; Guitiérrez Uribe, Janet Alejandra; Elizondo Martínez, Perla; Hernández Hernández, José Ascención; Aguilar Jimenéz, Oscar Alejandro
In early phase of drug development, New Chemical Entities (NCEs) are used as highly active drugs, with limited availability, and high cost. This study presents two alternatives of drug delivery systems, site-specific dendrimers and liposomes, with potenti
Novel bioengineering strategies for the recovery and purification of PEGylated lysozyme conjugates: in situ ATPS and affinity chromatography
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2017-07-13) Mejía Manzano, Luis Alberto; Mejía Manzano, Luis Alberto; 375359; Rito Palomares, Marco Antonio; Mayolo Deloisa, Karla Patricia; González Valdez, José Guillermo; Asenjo de Leuze, Juan A.; Parra Saldívar, Roberto
PEGylation is the modification of therapeutic proteins with polyethylene glycol (PEG) with the goal of improving their bioavailability and effectivity in the organism. During the PEGylation process, proteins with different degrees of PEGylation and positi