Ciencias Exactas y Ciencias de la Salud

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Self-Assembly behavior of amphiphilic janus dendrimers in water: a combined experimental and coarse-grained molecular dynamics simulation approach
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2018-05-14) Elizondo García, Mariana Estefanía; ELIZONDO GARCIA, MARIANA ESTEFANIA; 373696; Valencia Gallegos, Jesús Ángel; Videa Vargas, Marcelo Fernando; Gutiérrez Uribe, Janet Alejandra; González Nilo, Fernando Danilo; Cortéz Ramírez, Jorge
Amphiphilic Janus dendrimers (JDs) are repetitively branched molecules with hydrophilic and hydrophobic components that self-assemble in water to form a variety of morphologies, including vesicles analogous to liposomes with potential pharmaceutical and medical application. To date, the self-assembly of JDs has not been fully investigated thus it is important to gain insight into its mechanism and dependence on JDs’ molecular structure.
Controlled drug delivery strategies: Advances on the synthesis and molecular dynamics of dendrimers, and optimization of liposomes preparation by Dual Asymmetric Centrifugation
(Instituto Tecnológico y de Estudios Superiores de Monterrey, 2017-12-01) Sampogna Mireles, Diana; SAMPOGNA MIRELES, DIANA; 386013; Valencia Gallegos, Jesús Ángel; Guitiérrez Uribe, Janet Alejandra; Elizondo Martínez, Perla; Hernández Hernández, José Ascención; Aguilar Jimenéz, Oscar Alejandro
In early phase of drug development, New Chemical Entities (NCEs) are used as highly active drugs, with limited availability, and high cost. This study presents two alternatives of drug delivery systems, site-specific dendrimers and liposomes, with potenti

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